Methenamide
Methenamide Brand names, Methenamide Analogs
Methenamide Brand Names Mixture
- No information avaliable
Methenamide Chemical_Formula
C5H8N4O3S2
Methenamide RX_link
http://www.rxlist.com/cgi/generic2/methaz.htm
Methenamide fda sheet
Methenamide msds (material safety sheet)
Methenamide Synthesis Reference
Young, et al., J. Am. Chem. Soc. 78, 4649 (1956)
Methenamide Molecular Weight
236.274 g/mol
Methenamide Melting Point
213.5 oC
Methenamide H2O Solubility
3500 mg/L
Methenamide State
Solid
Methenamide LogP
0.231
Methenamide Dosage Forms
Tablet
Methenamide Indication
For treatment of chronic open-angle glaucoma and acute angle-closure glaucoma
Methenamide Pharmacology
Methazolamide is topical carbonic anhydrase inhibitor. Methazolamide is indicated for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to beta-blockers. Methazolamide is a sulfonamide derivative; however, it does not have any clinically significant antimicrobial properties. Although methazolamide achieves a high concentration in the cerebrospinal fluid, it is not-considered an effective anticonvulsant. Methazolamide has a weak and transient diuretic effect, therefore use results in an increase in urinary volume, with excretion of sodium, potassium and chloride.
Methenamide Absorption
Methazolamide is well absorbed from the gastrointestinal tract.
Methenamide side effects and Toxicity
Electrolyte imbalance, development of an acidotic state, and central nervous system effects might be expected to occur in the case of an overdose.
Methenamide Patient Information
Methenamide Organisms Affected
Humans and other mammals
