Mercaptopurine
Mercaptopurine Brand names, Mercaptopurine Analogs
Mercaptopurine Brand Names Mixture
- No information avaliable
Mercaptopurine Chemical_Formula
C5H4N4S
Mercaptopurine RX_link
http://www.rxlist.com/cgi/generic2/mercaptopurine.htm
Mercaptopurine fda sheet
Mercaptopurine msds (material safety sheet)
Mercaptopurine Synthesis Reference
No information avaliable
Mercaptopurine Molecular Weight
152.178 g/mol
Mercaptopurine Melting Point
313 oC
Mercaptopurine H2O Solubility
6.85 mg/mL
Mercaptopurine State
Solid
Mercaptopurine LogP
0.335
Mercaptopurine Dosage Forms
Tablet (50-mg, scored) for oral administration
Mercaptopurine Indication
For remission induction and maintenance therapy of acute lymphatic leukemia.
Mercaptopurine Pharmacology
Mercaptopurine is one of a large series of purine analogues which interfere with nucleic acid biosynthesis and has been found active against human leukemias. It is an analogue of the purine bases adenine and hypoxanthine. It is not known exactly which of any one or more of the biochemical effects of mercaptopurine and its metabolites are directly or predominantly responsible for cell death.
Mercaptopurine Absorption
Clinical studies have shown that the absorption of an oral dose of mercaptopurine in humans is incomplete and variable, averaging approximately 50% of the administered dose. The factors influencing absorption are unknown.
Mercaptopurine side effects and Toxicity
Signs and symptoms of overdosage may be immediate such as anorexia, nausea, vomiting, and diarrhea; or delayed such as myelosuppression, liver dysfunction, and gastroenteritis. The oral LD50 of mercaptopurine was determined to be 480 mg/kg in the mouse and 425 mg/kg in the rat.
Mercaptopurine Patient Information
No information avaliable
Mercaptopurine Organisms Affected
Humans and other mammals
