Meclophenamic acid
Meclophenamic acid Brand names, Meclophenamic acid Analogs
Meclophenamic acid Brand Names Mixture
- No information avaliable
Meclophenamic acid Chemical_Formula
C5H4N4S
Meclophenamic acid RX_link
http://www.rxlist.com/cgi/generic2/mercaptopurine.htm
Meclophenamic acid fda sheet
Meclophenamic acid msds (material safety sheet)
Meclophenamic acid Synthesis Reference
No information avaliable
Meclophenamic acid Molecular Weight
152.178 g/mol
Meclophenamic acid Melting Point
313 oC
Meclophenamic acid H2O Solubility
6.85 mg/mL
Meclophenamic acid State
Solid
Meclophenamic acid LogP
0.335
Meclophenamic acid Dosage Forms
Tablet (50-mg, scored) for oral administration
Meclophenamic acid Indication
For remission induction and maintenance therapy of acute lymphatic leukemia.
Meclophenamic acid Pharmacology
Mercaptopurine is one of a large series of purine analogues which interfere with nucleic acid biosynthesis and has been found active against human leukemias. It is an analogue of the purine bases adenine and hypoxanthine. It is not known exactly which of any one or more of the biochemical effects of mercaptopurine and its metabolites are directly or predominantly responsible for cell death.
Meclophenamic acid Absorption
Clinical studies have shown that the absorption of an oral dose of mercaptopurine in humans is incomplete and variable, averaging approximately 50% of the administered dose. The factors influencing absorption are unknown.
Meclophenamic acid side effects and Toxicity
Signs and symptoms of overdosage may be immediate such as anorexia, nausea, vomiting, and diarrhea; or delayed such as myelosuppression, liver dysfunction, and gastroenteritis. The oral LD50 of mercaptopurine was determined to be 480 mg/kg in the mouse and 425 mg/kg in the rat.
Meclophenamic acid Patient Information
No information avaliable
Meclophenamic acid Organisms Affected
Humans and other mammals
