Acidum meclofenamicum [INN-Latin] en es it fr

Acidum meclofenamicum [INN-Latin] Brand names, Acidum meclofenamicum [INN-Latin] Analogs

Acidum meclofenamicum [INN-Latin] Brand Names Mixture

  • No information avaliable

Acidum meclofenamicum [INN-Latin] Chemical_Formula

C5H4N4S

Acidum meclofenamicum [INN-Latin] RX_link

http://www.rxlist.com/cgi/generic2/mercaptopurine.htm

Acidum meclofenamicum [INN-Latin] fda sheet

Acidum_meclofenamicum_[INN-Latin] FDA

Acidum meclofenamicum [INN-Latin] msds (material safety sheet)

Acidum_meclofenamicum_[INN-Latin] MSDS

Acidum meclofenamicum [INN-Latin] Synthesis Reference

No information avaliable

Acidum meclofenamicum [INN-Latin] Molecular Weight

152.178 g/mol

Acidum meclofenamicum [INN-Latin] Melting Point

313 oC

Acidum meclofenamicum [INN-Latin] H2O Solubility

6.85 mg/mL

Acidum meclofenamicum [INN-Latin] State

Solid

Acidum meclofenamicum [INN-Latin] LogP

0.335

Acidum meclofenamicum [INN-Latin] Dosage Forms

Tablet (50-mg, scored) for oral administration

Acidum meclofenamicum [INN-Latin] Indication

For remission induction and maintenance therapy of acute lymphatic leukemia.

Acidum meclofenamicum [INN-Latin] Pharmacology

Mercaptopurine is one of a large series of purine analogues which interfere with nucleic acid biosynthesis and has been found active against human leukemias. It is an analogue of the purine bases adenine and hypoxanthine. It is not known exactly which of any one or more of the biochemical effects of mercaptopurine and its metabolites are directly or predominantly responsible for cell death.

Acidum meclofenamicum [INN-Latin] Absorption

Clinical studies have shown that the absorption of an oral dose of mercaptopurine in humans is incomplete and variable, averaging approximately 50% of the administered dose. The factors influencing absorption are unknown.

Acidum meclofenamicum [INN-Latin] side effects and Toxicity

Signs and symptoms of overdosage may be immediate such as anorexia, nausea, vomiting, and diarrhea; or delayed such as myelosuppression, liver dysfunction, and gastroenteritis. The oral LD50 of mercaptopurine was determined to be 480 mg/kg in the mouse and 425 mg/kg in the rat.

Acidum meclofenamicum [INN-Latin] Patient Information

No information avaliable

Acidum meclofenamicum [INN-Latin] Organisms Affected

Humans and other mammals