Meclofenamic acid(USAN) en es it fr

Meclofenamic acid(USAN) Brand names, Meclofenamic acid(USAN) Analogs

Meclofenamic acid(USAN) Brand Names Mixture

  • No information avaliable

Meclofenamic acid(USAN) Chemical_Formula

C5H4N4S

Meclofenamic acid(USAN) RX_link

http://www.rxlist.com/cgi/generic2/mercaptopurine.htm

Meclofenamic acid(USAN) fda sheet

Meclofenamic_acid(USAN) FDA

Meclofenamic acid(USAN) msds (material safety sheet)

Meclofenamic_acid(USAN) MSDS

Meclofenamic acid(USAN) Synthesis Reference

No information avaliable

Meclofenamic acid(USAN) Molecular Weight

152.178 g/mol

Meclofenamic acid(USAN) Melting Point

313 oC

Meclofenamic acid(USAN) H2O Solubility

6.85 mg/mL

Meclofenamic acid(USAN) State

Solid

Meclofenamic acid(USAN) LogP

0.335

Meclofenamic acid(USAN) Dosage Forms

Tablet (50-mg, scored) for oral administration

Meclofenamic acid(USAN) Indication

For remission induction and maintenance therapy of acute lymphatic leukemia.

Meclofenamic acid(USAN) Pharmacology

Mercaptopurine is one of a large series of purine analogues which interfere with nucleic acid biosynthesis and has been found active against human leukemias. It is an analogue of the purine bases adenine and hypoxanthine. It is not known exactly which of any one or more of the biochemical effects of mercaptopurine and its metabolites are directly or predominantly responsible for cell death.

Meclofenamic acid(USAN) Absorption

Clinical studies have shown that the absorption of an oral dose of mercaptopurine in humans is incomplete and variable, averaging approximately 50% of the administered dose. The factors influencing absorption are unknown.

Meclofenamic acid(USAN) side effects and Toxicity

Signs and symptoms of overdosage may be immediate such as anorexia, nausea, vomiting, and diarrhea; or delayed such as myelosuppression, liver dysfunction, and gastroenteritis. The oral LD50 of mercaptopurine was determined to be 480 mg/kg in the mouse and 425 mg/kg in the rat.

Meclofenamic acid(USAN) Patient Information

No information avaliable

Meclofenamic acid(USAN) Organisms Affected

Humans and other mammals