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Meclomen (free acid) Brand names, Meclomen (free acid) Analogs

Meclomen (free acid) Brand Names Mixture

  • No information avaliable

Meclomen (free acid) Chemical_Formula


Meclomen (free acid) RX_link

Meclomen (free acid) fda sheet

Meclomen_(free_acid) FDA

Meclomen (free acid) msds (material safety sheet)

Meclomen_(free_acid) MSDS

Meclomen (free acid) Synthesis Reference

No information avaliable

Meclomen (free acid) Molecular Weight

152.178 g/mol

Meclomen (free acid) Melting Point

313 oC

Meclomen (free acid) H2O Solubility

6.85 mg/mL

Meclomen (free acid) State


Meclomen (free acid) LogP


Meclomen (free acid) Dosage Forms

Tablet (50-mg, scored) for oral administration

Meclomen (free acid) Indication

For remission induction and maintenance therapy of acute lymphatic leukemia.

Meclomen (free acid) Pharmacology

Mercaptopurine is one of a large series of purine analogues which interfere with nucleic acid biosynthesis and has been found active against human leukemias. It is an analogue of the purine bases adenine and hypoxanthine. It is not known exactly which of any one or more of the biochemical effects of mercaptopurine and its metabolites are directly or predominantly responsible for cell death.

Meclomen (free acid) Absorption

Clinical studies have shown that the absorption of an oral dose of mercaptopurine in humans is incomplete and variable, averaging approximately 50% of the administered dose. The factors influencing absorption are unknown.

Meclomen (free acid) side effects and Toxicity

Signs and symptoms of overdosage may be immediate such as anorexia, nausea, vomiting, and diarrhea; or delayed such as myelosuppression, liver dysfunction, and gastroenteritis. The oral LD50 of mercaptopurine was determined to be 480 mg/kg in the mouse and 425 mg/kg in the rat.

Meclomen (free acid) Patient Information

No information avaliable

Meclomen (free acid) Organisms Affected

Humans and other mammals