Arquel
Arquel Brand names, Arquel Analogs
Arquel Brand Names Mixture
- No information avaliable
Arquel Chemical_Formula
C5H4N4S
Arquel RX_link
http://www.rxlist.com/cgi/generic2/mercaptopurine.htm
Arquel fda sheet
Arquel msds (material safety sheet)
Arquel Synthesis Reference
No information avaliable
Arquel Molecular Weight
152.178 g/mol
Arquel Melting Point
313 oC
Arquel H2O Solubility
6.85 mg/mL
Arquel State
Solid
Arquel LogP
0.335
Arquel Dosage Forms
Tablet (50-mg, scored) for oral administration
Arquel Indication
For remission induction and maintenance therapy of acute lymphatic leukemia.
Arquel Pharmacology
Mercaptopurine is one of a large series of purine analogues which interfere with nucleic acid biosynthesis and has been found active against human leukemias. It is an analogue of the purine bases adenine and hypoxanthine. It is not known exactly which of any one or more of the biochemical effects of mercaptopurine and its metabolites are directly or predominantly responsible for cell death.
Arquel Absorption
Clinical studies have shown that the absorption of an oral dose of mercaptopurine in humans is incomplete and variable, averaging approximately 50% of the administered dose. The factors influencing absorption are unknown.
Arquel side effects and Toxicity
Signs and symptoms of overdosage may be immediate such as anorexia, nausea, vomiting, and diarrhea; or delayed such as myelosuppression, liver dysfunction, and gastroenteritis. The oral LD50 of mercaptopurine was determined to be 480 mg/kg in the mouse and 425 mg/kg in the rat.
Arquel Patient Information
No information avaliable
Arquel Organisms Affected
Humans and other mammals
