Meclomen (free acid)
Meclomen (free acid) Brand names, Meclomen (free acid) Analogs
Meclomen (free acid) Brand Names Mixture
- No information avaliable
Meclomen (free acid) Chemical_Formula
C5H4N4S
Meclomen (free acid) RX_link
http://www.rxlist.com/cgi/generic2/mercaptopurine.htm
Meclomen (free acid) fda sheet
Meclomen (free acid) msds (material safety sheet)
Meclomen (free acid) Synthesis Reference
No information avaliable
Meclomen (free acid) Molecular Weight
152.178 g/mol
Meclomen (free acid) Melting Point
313 oC
Meclomen (free acid) H2O Solubility
6.85 mg/mL
Meclomen (free acid) State
Solid
Meclomen (free acid) LogP
0.335
Meclomen (free acid) Dosage Forms
Tablet (50-mg, scored) for oral administration
Meclomen (free acid) Indication
For remission induction and maintenance therapy of acute lymphatic leukemia.
Meclomen (free acid) Pharmacology
Mercaptopurine is one of a large series of purine analogues which interfere with nucleic acid biosynthesis and has been found active against human leukemias. It is an analogue of the purine bases adenine and hypoxanthine. It is not known exactly which of any one or more of the biochemical effects of mercaptopurine and its metabolites are directly or predominantly responsible for cell death.
Meclomen (free acid) Absorption
Clinical studies have shown that the absorption of an oral dose of mercaptopurine in humans is incomplete and variable, averaging approximately 50% of the administered dose. The factors influencing absorption are unknown.
Meclomen (free acid) side effects and Toxicity
Signs and symptoms of overdosage may be immediate such as anorexia, nausea, vomiting, and diarrhea; or delayed such as myelosuppression, liver dysfunction, and gastroenteritis. The oral LD50 of mercaptopurine was determined to be 480 mg/kg in the mouse and 425 mg/kg in the rat.
Meclomen (free acid) Patient Information
No information avaliable
Meclomen (free acid) Organisms Affected
Humans and other mammals
