Meclofenamic acid(USAN)
Meclofenamic acid(USAN) Brand names, Meclofenamic acid(USAN) Analogs
Meclofenamic acid(USAN) Brand Names Mixture
- No information avaliable
Meclofenamic acid(USAN) Chemical_Formula
C5H4N4S
Meclofenamic acid(USAN) RX_link
http://www.rxlist.com/cgi/generic2/mercaptopurine.htm
Meclofenamic acid(USAN) fda sheet
Meclofenamic acid(USAN) msds (material safety sheet)
Meclofenamic acid(USAN) Synthesis Reference
No information avaliable
Meclofenamic acid(USAN) Molecular Weight
152.178 g/mol
Meclofenamic acid(USAN) Melting Point
313 oC
Meclofenamic acid(USAN) H2O Solubility
6.85 mg/mL
Meclofenamic acid(USAN) State
Solid
Meclofenamic acid(USAN) LogP
0.335
Meclofenamic acid(USAN) Dosage Forms
Tablet (50-mg, scored) for oral administration
Meclofenamic acid(USAN) Indication
For remission induction and maintenance therapy of acute lymphatic leukemia.
Meclofenamic acid(USAN) Pharmacology
Mercaptopurine is one of a large series of purine analogues which interfere with nucleic acid biosynthesis and has been found active against human leukemias. It is an analogue of the purine bases adenine and hypoxanthine. It is not known exactly which of any one or more of the biochemical effects of mercaptopurine and its metabolites are directly or predominantly responsible for cell death.
Meclofenamic acid(USAN) Absorption
Clinical studies have shown that the absorption of an oral dose of mercaptopurine in humans is incomplete and variable, averaging approximately 50% of the administered dose. The factors influencing absorption are unknown.
Meclofenamic acid(USAN) side effects and Toxicity
Signs and symptoms of overdosage may be immediate such as anorexia, nausea, vomiting, and diarrhea; or delayed such as myelosuppression, liver dysfunction, and gastroenteritis. The oral LD50 of mercaptopurine was determined to be 480 mg/kg in the mouse and 425 mg/kg in the rat.
Meclofenamic acid(USAN) Patient Information
No information avaliable
Meclofenamic acid(USAN) Organisms Affected
Humans and other mammals
