Mannitol
Mannitol Brand names, Mannitol Analogs
Mannitol Brand Names Mixture
- No information avaliable
Mannitol Chemical_Formula
C6H14O6
Mannitol RX_link
http://www.rxlist.com/cgi/generic4/osmitrol.htm
Mannitol fda sheet
Mannitol msds (material safety sheet)
Mannitol Synthesis Reference
No information avaliable
Mannitol Molecular Weight
182.172 g/mol
Mannitol Melting Point
168 oC
Mannitol H2O Solubility
216 mg/mL
Mannitol State
Solid
Mannitol LogP
-3.506
Mannitol Dosage Forms
Liquid; Powder for solution; Solution
Mannitol Indication
Used for the promotion of diuresis before irreversible renal failure becomes established; The reduction of intracranial pressure, the treatment of cerebral edema, and the promotion of urinary excretion of toxic substances.
Mannitol Pharmacology
Chemically, mannitol is an alcohol and a sugar, or a polyol; it is similar to xylitol or sorbitol. However, mannitol has a tendency to lose a hydrogen ion in aqueous solutions, which causes the solution to become acidic. For this reason, it is not uncommon to add a substance to adjust its pH, such as sodium bicarbonate. Mannitol is commonly used to increase urine production (diuretic). It is also used to treat or prevent medical conditions that are caused by an increase in body fluids/water (e.g., cerebral edema, glaucoma, kidney failure). Mannitol is frequently given along with other diuretics (e.g., furosemide, chlorothiazide) and/or IV fluid replacement.
Mannitol Absorption
Approximately 7% of ingested mannitol is absorbed during gastrointestinal perfusion in uremic patients.
Mannitol side effects and Toxicity
LD50=1700 mg/kg (rat oral)
Mannitol Patient Information
Mannitol Organisms Affected
Humans and other mammals
