Mannitol

• Diuretics, Osmotic
• Sweetening Agents
• ATC:A06AD16
• ATC:B05BC01
• ATC:B05CX04

• Bareon
• LFLX
• Lomefloxacin [USAN:BAN:INN]
• Lomefloxacine [French]
• Lomefloxacino [Spanish]
• Lomefloxacinum [Latin]
• Maxaquin
• lomefloxacin hydrochloride

• No information avaliable

C₆H₁₄O₆

http://www.rxlist.com/cgi/generic4/osmitrol.htm

Mannitol MSDS

No information avaliable

182.172 g/mol

168 ^oC

216 mg/mL

Solid

-3.506

Liquid; Powder for solution; Solution

Used for the promotion of diuresis before irreversible renal failure becomes established; The reduction of intracranial pressure, the treatment of cerebral edema, and the promotion of urinary excretion of toxic substances.

Chemically, mannitol is an alcohol and a sugar, or a polyol; it is similar to xylitol or sorbitol. However, mannitol has a tendency to lose a hydrogen ion in aqueous solutions, which causes the solution to become acidic. For this reason, it is not uncommon to add a substance to adjust its pH, such as sodium bicarbonate. Mannitol is commonly used to increase urine production (diuretic). It is also used to treat or prevent medical conditions that are caused by an increase in body fluids/water (e.g., cerebral edema, glaucoma, kidney failure). Mannitol is frequently given along with other diuretics (e.g., furosemide, chlorothiazide) and/or IV fluid replacement.

Approximately 7% of ingested mannitol is absorbed during gastrointestinal perfusion in uremic patients.

LD₅₀=1700 mg/kg (rat oral)

Humans and other mammals