LFLX
LFLX Brand names, LFLX Analogs
LFLX Brand Names Mixture
- No information avaliable
LFLX Chemical_Formula
C6H14O6
LFLX RX_link
http://www.rxlist.com/cgi/generic4/osmitrol.htm
LFLX fda sheet
LFLX msds (material safety sheet)
LFLX Synthesis Reference
No information avaliable
LFLX Molecular Weight
182.172 g/mol
LFLX Melting Point
168 oC
LFLX H2O Solubility
216 mg/mL
LFLX State
Solid
LFLX LogP
-3.506
LFLX Dosage Forms
Liquid; Powder for solution; Solution
LFLX Indication
Used for the promotion of diuresis before irreversible renal failure becomes established; The reduction of intracranial pressure, the treatment of cerebral edema, and the promotion of urinary excretion of toxic substances.
LFLX Pharmacology
Chemically, mannitol is an alcohol and a sugar, or a polyol; it is similar to xylitol or sorbitol. However, mannitol has a tendency to lose a hydrogen ion in aqueous solutions, which causes the solution to become acidic. For this reason, it is not uncommon to add a substance to adjust its pH, such as sodium bicarbonate. Mannitol is commonly used to increase urine production (diuretic). It is also used to treat or prevent medical conditions that are caused by an increase in body fluids/water (e.g., cerebral edema, glaucoma, kidney failure). Mannitol is frequently given along with other diuretics (e.g., furosemide, chlorothiazide) and/or IV fluid replacement.
LFLX Absorption
Approximately 7% of ingested mannitol is absorbed during gastrointestinal perfusion in uremic patients.
LFLX side effects and Toxicity
LD50=1700 mg/kg (rat oral)
LFLX Patient Information
LFLX Organisms Affected
Humans and other mammals
