Lyovac Diuril [As Sodium Salt]

Lyovac Diuril [As Sodium Salt] Brand names, Lyovac Diuril [As Sodium Salt] Analogs

Lyovac Diuril [As Sodium Salt] Brand Names Mixture

Supres 150 Tab (Chlorothiazide + Methyldopa)
Supres 250 Tab (Chlorothiazide + Methyldopa)

Lyovac Diuril [As Sodium Salt] Chemical_Formula

C₇H₆ClN₃O₄S₂

Lyovac Diuril [As Sodium Salt] RX_link

http://www.rxlist.com/cgi/generic2/chloroth.htm

Lyovac Diuril [As Sodium Salt] fda sheet

Lyovac Diuril [As Sodium Salt] msds (material safety sheet)

Lyovac_Diuril_[As_Sodium_Salt] MSDS

Lyovac Diuril [As Sodium Salt] Synthesis Reference

No information avaliable

Lyovac Diuril [As Sodium Salt] Molecular Weight

295.725 g/mol

Lyovac Diuril [As Sodium Salt] Melting Point

350 ^oC

Lyovac Diuril [As Sodium Salt] H₂O Solubility

266 mg/L

Lyovac Diuril [As Sodium Salt] State

Solid

Lyovac Diuril [As Sodium Salt] LogP

0.549

Lyovac Diuril [As Sodium Salt] Dosage Forms

Tablet (250, 500 mg)

Lyovac Diuril [As Sodium Salt] Indication

Chlorothiazide is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. It is also indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension.

Lyovac Diuril [As Sodium Salt] Pharmacology

Like other thiazides, chlorothiazide promotes water loss from the body (diuretics). It inhibits Na⁺/Cl^- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue. Chlorothiazide affects the distal renal tubular mechanism of electrolyte reabsorption. At maximal therapeutic dosages, all thiazides are approximately equal in their diuretic efficacy. Chlorothiazide increases excretion of sodium and chloride in approximately equivalent amounts. Natriuresis may be accompanied by some loss of potassium and bicarbonate.

Lyovac Diuril [As Sodium Salt] Absorption