Chlorthiazide

Chlorthiazide Brand names, Chlorthiazide Analogs

Chlorthiazide Brand Names Mixture

Supres 150 Tab (Chlorothiazide + Methyldopa)
Supres 250 Tab (Chlorothiazide + Methyldopa)

Chlorthiazide Chemical_Formula

C₇H₆ClN₃O₄S₂

Chlorthiazide RX_link

http://www.rxlist.com/cgi/generic2/chloroth.htm

Chlorthiazide fda sheet

Chlorthiazide msds (material safety sheet)

Chlorthiazide MSDS

Chlorthiazide Synthesis Reference

No information avaliable

Chlorthiazide Molecular Weight

295.725 g/mol

Chlorthiazide Melting Point

350 ^oC

Chlorthiazide H₂O Solubility

266 mg/L

Chlorthiazide State

Solid

Chlorthiazide LogP

0.549

Chlorthiazide Dosage Forms

Tablet (250, 500 mg)

Chlorthiazide Indication

Chlorothiazide is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. It is also indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension.

Chlorthiazide Pharmacology

Like other thiazides, chlorothiazide promotes water loss from the body (diuretics). It inhibits Na⁺/Cl^- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue. Chlorothiazide affects the distal renal tubular mechanism of electrolyte reabsorption. At maximal therapeutic dosages, all thiazides are approximately equal in their diuretic efficacy. Chlorothiazide increases excretion of sodium and chloride in approximately equivalent amounts. Natriuresis may be accompanied by some loss of potassium and bicarbonate.

Chlorthiazide Absorption