Levamisole
Levamisole Brand names, Levamisole Analogs
Levamisole Brand Names Mixture
- No information avaliable
Levamisole Chemical_Formula
C11H12N2S
Levamisole RX_link
http://www.rxlist.com/cgi/generic3/levamisole.htm
Levamisole fda sheet
Levamisole msds (material safety sheet)
Levamisole Synthesis Reference
No information avaliable
Levamisole Molecular Weight
204.292 g/mol
Levamisole Melting Point
264-265 oC
Levamisole H2O Solubility
210 mg/mL
Levamisole State
Solid
Levamisole LogP
2.046
Levamisole Dosage Forms
Tablet
Levamisole Indication
For adjuvant treatment in combination with fluorouracil after surgical resection in patients with Dukes' stage C colon cancer. Also used to treat malignant melanoma and head/neck cancer.
Levamisole Pharmacology
Levamisole is a synthetic imidazothiazole derivative that has been widely used in treatment of worm infestations in both humans and animals. As an anthelmintic, it probably works by targeting the nematode nicotinergic acetylcholine receptor. As an immunomodulator, it appears that Levamisole is an immunostimulant which has been shown to increase NK cells and activated T-cells in patients receiving this adjuvantly along with 5FU for Stage III colon cancer.
Levamisole Absorption
Levamisole is rapidly absorbed (2 hours) from the gastrointestinal tract.
Levamisole side effects and Toxicity
LD50 = 40 mg/kg (Pigs, subcutaneous); LD50 = 180 mg/kg (rat, oral)
Levamisole Patient Information
http://www.drugs.com/MTM/letrozole.html
Levamisole Organisms Affected
Humans and other mammals
