Ketotifene [INN-French]

Ketotifene [INN-French] Brand names, Ketotifene [INN-French] Analogs

Ketotifene [INN-French] Brand Names Mixture

No information avaliable

Ketotifene [INN-French] Chemical_Formula

C₁₁H₁₂N₂S

Ketotifene [INN-French] RX_link

http://www.rxlist.com/cgi/generic3/levamisole.htm

Ketotifene [INN-French] fda sheet

Ketotifene_[INN-French] FDA

Ketotifene [INN-French] msds (material safety sheet)

Ketotifene_[INN-French] MSDS

Ketotifene [INN-French] Synthesis Reference

No information avaliable

Ketotifene [INN-French] Molecular Weight

204.292 g/mol

Ketotifene [INN-French] Melting Point

264-265 ^oC

Ketotifene [INN-French] H₂O Solubility

210 mg/mL

Ketotifene [INN-French] State

Solid

Ketotifene [INN-French] LogP

2.046

Ketotifene [INN-French] Dosage Forms

Tablet

Ketotifene [INN-French] Indication

For adjuvant treatment in combination with fluorouracil after surgical resection in patients with Dukes' stage C colon cancer. Also used to treat malignant melanoma and head/neck cancer.

Ketotifene [INN-French] Pharmacology

Levamisole is a synthetic imidazothiazole derivative that has been widely used in treatment of worm infestations in both humans and animals. As an anthelmintic, it probably works by targeting the nematode nicotinergic acetylcholine receptor. As an immunomodulator, it appears that Levamisole is an immunostimulant which has been shown to increase NK cells and activated T-cells in patients receiving this adjuvantly along with 5FU for Stage III colon cancer.

Ketotifene [INN-French] Absorption

Levamisole is rapidly absorbed (2 hours) from the gastrointestinal tract.

Ketotifene [INN-French] side effects and Toxicity

LD₅₀ = 40 mg/kg (Pigs, subcutaneous); LD₅₀ = 180 mg/kg (rat, oral)

Ketotifene [INN-French] Patient Information

http://www.drugs.com/MTM/letrozole.html

Ketotifene [INN-French] Organisms Affected

Humans and other mammals