Levamisole

AMERICAN CYANAMID CO. PARSIPPANY, NJ 07054 MSDS NO. AG09957-3 MATERIAL SAFETY DATA SHEET CAS NO. Mixture DATE: JUN 02, 1997 EMERGENCY TELEPHONE: (973)-683-3100 (U.S.A.) _______________________________________________________________________________ PRODUCT TRADE NAME: TRAMISOL LEVAMISOLE POUR-ON IDENTIFICATION SYNONYMS: L-(-)-2,3,5,6-tetrahydro-6-phenylimidazo [2',1-b]Thiozole-diethylene glycol monobutyl ether (DGBE); Levamisole Hydrochloride; RIPERCOL Levamisole Pour-On CHEMICAL FAMILY: Imidazothiozole MOLECULAR FORMULA: C<8>H<18>O<3> C<11>H<12>N<2>S.HCl MOLECULAR WEIGHT: 162.220 Diethylene Glycol Monobutyl Ether (DGBE) 240.760 Levamisole Hydrochloride USAGE: Dewormer _______________________________________________________________________________ WARNING CAUTION: STATEMENTS KEEP OUT OF REACH OF CHILDREN. AVOID CONTACT WITH SKIN OR EYES. _______________________________________________________________________________ INGREDIENTS COMPONENT CAS. NO. % PEL/TLV Diethylene Glycol 112-34-5 ~80.00 None Established Monobutyl Ether (DGBE) Levamisole 16595-80-5 ~20.00 2.5 mg/m>3< TWA Hydrochloride 5.0 mg/m>3< (STEL) ____________________________________________________________________________ REFERENCE: Diethylene Glycol None Monobutyl Ether (DGBE) Levamisole Cyanamid - 1984 Hydrochloride _______________________________________________________________________________ PHYSICAL APPEARANCE AND Odorless liquid (DGBE) PROPERTIES ODOR: BOILING POINT: 230.4C (DGBE) MELTING POINT: -68.1C (DGBE) VAPOR PRESSURE: 0.02 mm @ 20 (DGBE) SPECIFIC GRAVITY: 0.95 (DGBE) VAPOR DENSITY: 5.6 (Air = 1) (DGBE) % VOLATILITY (BY Not Available VOL.): OCTANOL / H<2>O Not Available PARTITION COEF.: PH: Not Available SATURATION IN Not Available AIR (BY VOL.):  MSDS SHEET NO. AG09957-3 PAGE 2 _______________________________________________________________________________ EVAPORATION RATE: 0.01 (N-Butyl acetate = 1) (DGBE) SOLUBILITY IN Miscible in water _______________________________________________________________________________ FIRE AND FLASH POINT: 220F (DGBE) EXPLOSION FLAMMABLE LIMITS Not Available HAZARD (% BY VOL.): INFORMATION AUTOIGNITION TEMP: 442 (DGBE) DECOMPOSITION TEMP:Not Available FIRE EXTINGUISHING MEDIA: Use water, foam, dry chemical or carbon dioxide to extinguish fires. FIRE CONTROL TACTICS: Wear self-contained, positive pressure breathing apparatus and full fire fighting protective clothing. Keep unnecessary people away. Use as little water as possible. Dike area of fire to prevent run-off. Use spray or fog - solid stream may cause spreading. Do not decontaminate personnel or equipment or handle broken packages or containers without protective equipment as specified in the Exposure Control Section. Avoid breathing dusts, vapors and fumes from burning materials. Control run-off water - if water enters a drainage system, advise the authorities downstream. _______________________________________________________________________________ NFPA HAZARD RATING 0 Least 1 Flammability 1 Slight / \ / \ 2 Moderate 1 0 Health Reactivity 3 High \ / \ / 4 Severe Special _______________________________________________________________________________ REACTIVITY DATA STABILITY: Stable CONDITIONS TO AVOID: Avoid heat, flame, and contact with strong oxidizing agents. Avoid contact with aluminum surfaces. POLYMERIZATION: Will not occur CONDITIONS TO AVOID: None known INCOMPATIBLE None known MATERIALS: HAZARDOUS Carbon monoxide and unidentified DECOMPOSITION organic compounds may be formed PRODUCTS: during decomposition. _______________________________________________________________________________ HEALTH HAZARD TOXICITY DATA AND INFORMATION EFFECTS OF OVEREXPOSURE: ACUTE TOXICITY DATA: There is no toxicity data on this particular formulation. The information provided below refers to the 80%  MSDS SHEET NO. AG09957-3 PAGE 3 _______________________________________________________________________________ diethylene glycol monobutyl ether content in the formulation. Glycol ethers as a class are not normally acutely hazardous by the oral route. However, glycol ethers, particularly the ethylene series in high vapor concentrations are sometimes lethal. In addition, the ethylene series have recently been shown to have the potential to induce reproductive toxicity in a number of animal studies. The acute oral LD<50> of DGBE in rats has been shown to range between 5.7-6.6 g/kg indicating that the material is practically non-toxic by single oral administration. The acute dermal LD<50> in rabbits has been reported at 4.0 g/kg. indicating the material is practically non-toxic by single skin application. The material is moderately irritating to the eyes and is slightly irritating to the skin. EMERGENCY AND FIRST AID PROCEDURES: : Drink two large glasses of water. Induce vomiting by touching the back of the throat with fingers. Do not give liquids or induce vomiting if patient is unconscious. : Flush eyes with copious amounts of water for at least 15 minutes while holding eyelids open. Get medical attention if irritation persists. : Wash skin with plenty of soap and water. Get medical attention if irritation persists. : Remove subject to fresh air and provide oxygen, if breathing is difficult. Get medical attention. NOTES TO PHYSICIAN: Atropine and other anticholinergic drugs are only partially effective as antidotes. The use of a ganglionic blocking agent may be required to treat severe intoxication with arrhythmias and respiratory difficulties. If flaccid paralysis occurs, drugs are useless and respiratory assistance should be given while the drug is metabolized. A preparation for humans, mecamylamine (Iversine, Merck) is the ganglionic blocker of choice. It should be given subcutaneously starting at 1 to 2 mg to effect. Diazepam has been used as an effective antidote in experimental animals.  MSDS SHEET NO. AG09957-3 PAGE 4 _______________________________________________________________________________ MEDICAL CONDITION AGGRAVATED BY OVEREXPOSURE: A knowledge of the available toxicology information and of the physical and chemical properties of the material suggests that overexposure is unlikely to aggravate existing medical conditions. _______________________________________________________________________________ EXPOSURE During formulation of this product, the following good CONTROL METHODS industrial hygiene practice is recommended: Provide adequate local ventilation and maintain a Permissible Exposure Limit below the level recommended for the various components of the product. If vapor levels exceed the recommended PEL, an approved pesticide respirator should be worn until engineering controls are achieved. Chemical goggles or some other form of eye protection should be worn to prevent exposure to the eyes. Wear rubber gloves when handling this material. An apron or impermeable covering should be worn where splashing could occur. Wash thoroughly with soap and water after handling. Remove contaminated clothing and wash before reuse. For end-users, please refer to the product label for personal protective clothing/equipment. _______________________________________________________________________________ SPILL OR LEAK Wearing appropriate protective clothing and equipment (see PROCEDURES "Exposure Control" section), dike spill area to prevent product release, absorb with an inert absorbent material, (e.g. granular clay or sawdust), and shovel/sweep into covered containers for proper disposal (see "Waste Disposal" section). Small spills to the soil can be shoveled directly into disposal containers. In the event of a large spill, contact Cyanamid for guidance on available clean-up options. ____________________________________________________________________________ WASTE DISPOSAL: To avoid disposal, all attempts should be made to utilize the product completely, in accordance with its intended and/or registered use. If this is not possible, follow all applicable Federal, State, Provincial and Local regulations regarding waste management methods. _______________________________________________________________________________  MSDS SHEET NO. AG09957-3 *** WARNING! THIS MSDS IS NOT ACTIVE *** PAGE 5 _______________________________________________________________________________ SPECIAL HANDLING AND STORAGE: PRECAUTIONS Do not contaminate water, food, or feed by storage or disposal. Store in a secure, dry, well-ventilated separate area; away from children, livestock and food products. Not for use or storage in or around the home. Keep away from sources of ignition and protect from exposure to fire and heat. _______________________________________________________________________________ APPENDIX The information and statements herein are believed to be reliable but are not to be construed as a warranty or representation for which we assume legal responsibility. Users should undertake sufficient verification and testing to determine the suitability for their own particular purpose of any information or products referred to herein. NO WARRANTY OF FITNESS FOR A PARTICULAR PURPOSE IS MADE. Last Revision Date: 9/11/91 _______________________________________________________________________________ SOURCE AND SHEET NO.: AG09957-3 DATE INFORMATION DATE: JUN 02, 1997 _______________________________________________________________________________