Leucovorin calcium preservative free en es it fr

Leucovorin calcium preservative free Brand names, Leucovorin calcium preservative free Analogs

Leucovorin calcium preservative free Brand Names Mixture

  • No information avaliable

Leucovorin calcium preservative free Chemical_Formula

C20H23N7O7

Leucovorin calcium preservative free RX_link

http://www.rxlist.com/cgi/generic2/leucovorin.htm

Leucovorin calcium preservative free fda sheet

Leucovorin_calcium_preservative_free FDA

Leucovorin calcium preservative free msds (material safety sheet)

Leucovorin_calcium_preservative_free MSDS

Leucovorin calcium preservative free Synthesis Reference

No information avaliable

Leucovorin calcium preservative free Molecular Weight

473.44 g/mol

Leucovorin calcium preservative free Melting Point

No information avaliable

Leucovorin calcium preservative free H2O Solubility

Complete

Leucovorin calcium preservative free State

Solid

Leucovorin calcium preservative free LogP

-1.744

Leucovorin calcium preservative free Dosage Forms

Liquid; Powder for solution; Solution; Tablet

Leucovorin calcium preservative free Indication

For the treatment of osteosarcoma (after high dose methotrexate therapy). Used to diminish the toxicity and counteract the effects of impaired methotrexate elimination and of inadvertent overdosages of folic acid antagonists, and to treat megaloblastic anemias due to folic acid deficiency. Also used in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced colorectal cancer.

Leucovorin calcium preservative free Pharmacology

Leucovorin is one of several active, chemically reduced derivatives of folic acid. It is useful as an antidote to drugs which act as folic acid antagonists. Leucovorin is a mixture of the diastereoisomers of the 5-formyl derivative of tetrahydrofolic acid (THF). The biologically active compound of the mixture is the (-)-l-isomer, known as Citrovorum factor or (-)-folinic acid. Leucovorin does not require reduction by the enzyme dihydrofolate reductase in order to participate in reactions utilizing folates as a source of “one-carbon” moieties. Administration of leucovorin can counteract the therapeutic and toxic effects of folic acid antagonists such as methotrexate, which act by inhibiting dihydrofolate reductase. Leucovorin has also been used to enhance the activity of fluorouracil.

Leucovorin calcium preservative free Absorption

Following oral administration, leucovorin is rapidly absorbed. The apparent bioavailability of leucovorin was 97% for 25 mg, 75% for 50 mg, and 37% for 100 mg.

Leucovorin calcium preservative free side effects and Toxicity

LD50>8000 mg/kg (orally in rats). Excessive amounts of leucovorin may nullify the chemotherapeutic effect of folic acid antagonists.

Leucovorin calcium preservative free Patient Information

No information avaliable

Leucovorin calcium preservative free Organisms Affected

Humans and other mammals