Citrovorum factor en es it fr

Citrovorum factor Brand names, Citrovorum factor Analogs

Citrovorum factor Brand Names Mixture

  • No information avaliable

Citrovorum factor Chemical_Formula


Citrovorum factor RX_link

Citrovorum factor fda sheet

Citrovorum_factor FDA

Citrovorum factor msds (material safety sheet)

Citrovorum_factor MSDS

Citrovorum factor Synthesis Reference

No information avaliable

Citrovorum factor Molecular Weight

473.44 g/mol

Citrovorum factor Melting Point

No information avaliable

Citrovorum factor H2O Solubility


Citrovorum factor State


Citrovorum factor LogP


Citrovorum factor Dosage Forms

Liquid; Powder for solution; Solution; Tablet

Citrovorum factor Indication

For the treatment of osteosarcoma (after high dose methotrexate therapy). Used to diminish the toxicity and counteract the effects of impaired methotrexate elimination and of inadvertent overdosages of folic acid antagonists, and to treat megaloblastic anemias due to folic acid deficiency. Also used in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced colorectal cancer.

Citrovorum factor Pharmacology

Leucovorin is one of several active, chemically reduced derivatives of folic acid. It is useful as an antidote to drugs which act as folic acid antagonists. Leucovorin is a mixture of the diastereoisomers of the 5-formyl derivative of tetrahydrofolic acid (THF). The biologically active compound of the mixture is the (-)-l-isomer, known as Citrovorum factor or (-)-folinic acid. Leucovorin does not require reduction by the enzyme dihydrofolate reductase in order to participate in reactions utilizing folates as a source of “one-carbon” moieties. Administration of leucovorin can counteract the therapeutic and toxic effects of folic acid antagonists such as methotrexate, which act by inhibiting dihydrofolate reductase. Leucovorin has also been used to enhance the activity of fluorouracil.

Citrovorum factor Absorption

Following oral administration, leucovorin is rapidly absorbed. The apparent bioavailability of leucovorin was 97% for 25 mg, 75% for 50 mg, and 37% for 100 mg.

Citrovorum factor side effects and Toxicity

LD50>8000 mg/kg (orally in rats). Excessive amounts of leucovorin may nullify the chemotherapeutic effect of folic acid antagonists.

Citrovorum factor Patient Information

No information avaliable

Citrovorum factor Organisms Affected

Humans and other mammals