Folinic acid calcium salt USP27 en es it fr

Folinic acid calcium salt USP27 Brand names, Folinic acid calcium salt USP27 Analogs

Folinic acid calcium salt USP27 Brand Names Mixture

  • No information avaliable

Folinic acid calcium salt USP27 Chemical_Formula

C20H23N7O7

Folinic acid calcium salt USP27 RX_link

http://www.rxlist.com/cgi/generic2/leucovorin.htm

Folinic acid calcium salt USP27 fda sheet

Folinic_acid_calcium_salt_USP27 FDA

Folinic acid calcium salt USP27 msds (material safety sheet)

Folinic_acid_calcium_salt_USP27 MSDS

Folinic acid calcium salt USP27 Synthesis Reference

No information avaliable

Folinic acid calcium salt USP27 Molecular Weight

473.44 g/mol

Folinic acid calcium salt USP27 Melting Point

No information avaliable

Folinic acid calcium salt USP27 H2O Solubility

Complete

Folinic acid calcium salt USP27 State

Solid

Folinic acid calcium salt USP27 LogP

-1.744

Folinic acid calcium salt USP27 Dosage Forms

Liquid; Powder for solution; Solution; Tablet

Folinic acid calcium salt USP27 Indication

For the treatment of osteosarcoma (after high dose methotrexate therapy). Used to diminish the toxicity and counteract the effects of impaired methotrexate elimination and of inadvertent overdosages of folic acid antagonists, and to treat megaloblastic anemias due to folic acid deficiency. Also used in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced colorectal cancer.

Folinic acid calcium salt USP27 Pharmacology

Leucovorin is one of several active, chemically reduced derivatives of folic acid. It is useful as an antidote to drugs which act as folic acid antagonists. Leucovorin is a mixture of the diastereoisomers of the 5-formyl derivative of tetrahydrofolic acid (THF). The biologically active compound of the mixture is the (-)-l-isomer, known as Citrovorum factor or (-)-folinic acid. Leucovorin does not require reduction by the enzyme dihydrofolate reductase in order to participate in reactions utilizing folates as a source of “one-carbon” moieties. Administration of leucovorin can counteract the therapeutic and toxic effects of folic acid antagonists such as methotrexate, which act by inhibiting dihydrofolate reductase. Leucovorin has also been used to enhance the activity of fluorouracil.

Folinic acid calcium salt USP27 Absorption

Following oral administration, leucovorin is rapidly absorbed. The apparent bioavailability of leucovorin was 97% for 25 mg, 75% for 50 mg, and 37% for 100 mg.

Folinic acid calcium salt USP27 side effects and Toxicity

LD50>8000 mg/kg (orally in rats). Excessive amounts of leucovorin may nullify the chemotherapeutic effect of folic acid antagonists.

Folinic acid calcium salt USP27 Patient Information

No information avaliable

Folinic acid calcium salt USP27 Organisms Affected

Humans and other mammals