Folinic acid-SF en es it fr

Folinic acid-SF Brand names, Folinic acid-SF Analogs

Folinic acid-SF Brand Names Mixture

  • No information avaliable

Folinic acid-SF Chemical_Formula


Folinic acid-SF RX_link

Folinic acid-SF fda sheet

Folinic_acid-SF FDA

Folinic acid-SF msds (material safety sheet)

Folinic_acid-SF MSDS

Folinic acid-SF Synthesis Reference

No information avaliable

Folinic acid-SF Molecular Weight

473.44 g/mol

Folinic acid-SF Melting Point

No information avaliable

Folinic acid-SF H2O Solubility


Folinic acid-SF State


Folinic acid-SF LogP


Folinic acid-SF Dosage Forms

Liquid; Powder for solution; Solution; Tablet

Folinic acid-SF Indication

For the treatment of osteosarcoma (after high dose methotrexate therapy). Used to diminish the toxicity and counteract the effects of impaired methotrexate elimination and of inadvertent overdosages of folic acid antagonists, and to treat megaloblastic anemias due to folic acid deficiency. Also used in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced colorectal cancer.

Folinic acid-SF Pharmacology

Leucovorin is one of several active, chemically reduced derivatives of folic acid. It is useful as an antidote to drugs which act as folic acid antagonists. Leucovorin is a mixture of the diastereoisomers of the 5-formyl derivative of tetrahydrofolic acid (THF). The biologically active compound of the mixture is the (-)-l-isomer, known as Citrovorum factor or (-)-folinic acid. Leucovorin does not require reduction by the enzyme dihydrofolate reductase in order to participate in reactions utilizing folates as a source of “one-carbon” moieties. Administration of leucovorin can counteract the therapeutic and toxic effects of folic acid antagonists such as methotrexate, which act by inhibiting dihydrofolate reductase. Leucovorin has also been used to enhance the activity of fluorouracil.

Folinic acid-SF Absorption

Following oral administration, leucovorin is rapidly absorbed. The apparent bioavailability of leucovorin was 97% for 25 mg, 75% for 50 mg, and 37% for 100 mg.

Folinic acid-SF side effects and Toxicity

LD50>8000 mg/kg (orally in rats). Excessive amounts of leucovorin may nullify the chemotherapeutic effect of folic acid antagonists.

Folinic acid-SF Patient Information

No information avaliable

Folinic acid-SF Organisms Affected

Humans and other mammals