L-Apomorphine
Brand names,
L-Apomorphine
Analogs
L-Apomorphine
Brand Names Mixture
- Homeopathic Remedy Thc No. 48 Dps (Antimony Trisulfide + Apomorphine + Ipecac + Phosphorus + Pulsatilla)
L-Apomorphine
Chemical_Formula
C17H17NO2
L-Apomorphine
RX_link
http://www.rxlist.com/cgi/generic3/apokyn.htm
L-Apomorphine
fda sheet
L-Apomorphine
msds (material safety sheet)
L-Apomorphine
Synthesis Reference
J. L. Neumeyer et al., J. Pharm. Sci. 59, 1850 (1970);
L-Apomorphine
Molecular Weight
267.322 g/mol
L-Apomorphine
Melting Point
No information avaliable
L-Apomorphine
H2O Solubility
1.66E+004 mg/L
L-Apomorphine
State
Solid
L-Apomorphine
LogP
3.03
L-Apomorphine
Dosage Forms
Subcutaneous solution (not for IV)
L-Apomorphine
Indication
For the acute, intermittent treatment of hypomobility, off episodes (end-of-dose wearing off and unpredictable on/off episodes) associated with advanced Parkinson's disease.
L-Apomorphine
Pharmacology
Apomorphine is a type of dopaminergic agonist, a morphine derivative which primarily affects the hypothalamic region of the brain. Drugs containing this substance are sometimes used in the treatment of Parkinson's disease or erectile dysfunction. In higher doses it is a highly effective emetic.
L-Apomorphine
Absorption
100% following subcutaneous administration
L-Apomorphine
side effects and Toxicity
LD50=0.6 mmoles/kg (mice, intraperitoneal)
L-Apomorphine
Patient Information
L-Apomorphine
Organisms Affected
Humans and other mammals