Apomorphine Hydrochloride Hemihydrate
Brand names,
Apomorphine Hydrochloride Hemihydrate
Analogs
Apomorphine Hydrochloride Hemihydrate
Brand Names Mixture
- Homeopathic Remedy Thc No. 48 Dps (Antimony Trisulfide + Apomorphine + Ipecac + Phosphorus + Pulsatilla)
Apomorphine Hydrochloride Hemihydrate
Chemical_Formula
C17H17NO2
Apomorphine Hydrochloride Hemihydrate
RX_link
http://www.rxlist.com/cgi/generic3/apokyn.htm
Apomorphine Hydrochloride Hemihydrate
fda sheet
Apomorphine Hydrochloride Hemihydrate
msds (material safety sheet)
Apomorphine Hydrochloride Hemihydrate
Synthesis Reference
J. L. Neumeyer et al., J. Pharm. Sci. 59, 1850 (1970);
Apomorphine Hydrochloride Hemihydrate
Molecular Weight
267.322 g/mol
Apomorphine Hydrochloride Hemihydrate
Melting Point
No information avaliable
Apomorphine Hydrochloride Hemihydrate
H2O Solubility
1.66E+004 mg/L
Apomorphine Hydrochloride Hemihydrate
State
Solid
Apomorphine Hydrochloride Hemihydrate
LogP
3.03
Apomorphine Hydrochloride Hemihydrate
Dosage Forms
Subcutaneous solution (not for IV)
Apomorphine Hydrochloride Hemihydrate
Indication
For the acute, intermittent treatment of hypomobility, off episodes (end-of-dose wearing off and unpredictable on/off episodes) associated with advanced Parkinson's disease.
Apomorphine Hydrochloride Hemihydrate
Pharmacology
Apomorphine is a type of dopaminergic agonist, a morphine derivative which primarily affects the hypothalamic region of the brain. Drugs containing this substance are sometimes used in the treatment of Parkinson's disease or erectile dysfunction. In higher doses it is a highly effective emetic.
Apomorphine Hydrochloride Hemihydrate
Absorption
100% following subcutaneous administration
Apomorphine Hydrochloride Hemihydrate
side effects and Toxicity
LD50=0.6 mmoles/kg (mice, intraperitoneal)
Apomorphine Hydrochloride Hemihydrate
Patient Information
Apomorphine Hydrochloride Hemihydrate
Organisms Affected
Humans and other mammals