Apomorfin
Brand names,
Apomorfin
Analogs
Apomorfin
Brand Names Mixture
- Homeopathic Remedy Thc No. 48 Dps (Antimony Trisulfide + Apomorphine + Ipecac + Phosphorus + Pulsatilla)
Apomorfin
Chemical_Formula
C17H17NO2
Apomorfin
RX_link
http://www.rxlist.com/cgi/generic3/apokyn.htm
Apomorfin
fda sheet
Apomorfin
msds (material safety sheet)
Apomorfin
Synthesis Reference
J. L. Neumeyer et al., J. Pharm. Sci. 59, 1850 (1970);
Apomorfin
Molecular Weight
267.322 g/mol
Apomorfin
Melting Point
No information avaliable
Apomorfin
H2O Solubility
1.66E+004 mg/L
Apomorfin
State
Solid
Apomorfin
LogP
3.03
Apomorfin
Dosage Forms
Subcutaneous solution (not for IV)
Apomorfin
Indication
For the acute, intermittent treatment of hypomobility, off episodes (end-of-dose wearing off and unpredictable on/off episodes) associated with advanced Parkinson's disease.
Apomorfin
Pharmacology
Apomorphine is a type of dopaminergic agonist, a morphine derivative which primarily affects the hypothalamic region of the brain. Drugs containing this substance are sometimes used in the treatment of Parkinson's disease or erectile dysfunction. In higher doses it is a highly effective emetic.
Apomorfin
Absorption
100% following subcutaneous administration
Apomorfin
side effects and Toxicity
LD50=0.6 mmoles/kg (mice, intraperitoneal)
Apomorfin
Patient Information
Apomorfin
Organisms Affected
Humans and other mammals