Apormorphine
Brand names,
Apormorphine
Analogs
Apormorphine
Brand Names Mixture
- Homeopathic Remedy Thc No. 48 Dps (Antimony Trisulfide + Apomorphine + Ipecac + Phosphorus + Pulsatilla)
Apormorphine
Chemical_Formula
C17H17NO2
Apormorphine
RX_link
http://www.rxlist.com/cgi/generic3/apokyn.htm
Apormorphine
fda sheet
Apormorphine
msds (material safety sheet)
Apormorphine
Synthesis Reference
J. L. Neumeyer et al., J. Pharm. Sci. 59, 1850 (1970);
Apormorphine
Molecular Weight
267.322 g/mol
Apormorphine
Melting Point
No information avaliable
Apormorphine
H2O Solubility
1.66E+004 mg/L
Apormorphine
State
Solid
Apormorphine
LogP
3.03
Apormorphine
Dosage Forms
Subcutaneous solution (not for IV)
Apormorphine
Indication
For the acute, intermittent treatment of hypomobility, off episodes (end-of-dose wearing off and unpredictable on/off episodes) associated with advanced Parkinson's disease.
Apormorphine
Pharmacology
Apomorphine is a type of dopaminergic agonist, a morphine derivative which primarily affects the hypothalamic region of the brain. Drugs containing this substance are sometimes used in the treatment of Parkinson's disease or erectile dysfunction. In higher doses it is a highly effective emetic.
Apormorphine
Absorption
100% following subcutaneous administration
Apormorphine
side effects and Toxicity
LD50=0.6 mmoles/kg (mice, intraperitoneal)
Apormorphine
Patient Information
Apormorphine
Organisms Affected
Humans and other mammals