Indapamide

Indapamide Brand names, Indapamide Analogs

Indapamide Brand Names Mixture

No information avaliable

Indapamide Chemical_Formula

C₁₆H₁₆ClN₃O₃S

Indapamide RX_link

http://www.rxlist.com/cgi/generic/indap.htm

Indapamide fda sheet

Indapamide FDA

Indapamide msds (material safety sheet)

Indapamide MSDS

Indapamide Synthesis Reference

No information avaliable

Indapamide Molecular Weight

365.835 g/mol

Indapamide Melting Point

161 ^oC

Indapamide H₂O Solubility

75 mg/L

Indapamide State

Solid

Indapamide LogP

2.088

Indapamide Dosage Forms

Tablet

Indapamide Indication

For the treatment of hypertension, alone or in combination with other antihypertensive drugs as well as for the treatment of salt and fluid retention associated with congestive heart failure or edema from pregnancy.

Indapamide Pharmacology

Indapamide is an antihypertensive and a diuretic. It contains both a polar sulfamoyl chlorobenzamide moiety and a lipid- soluble methylindoline moiety. Indapamide bears a structural similarity to the triazide diuretics which are known to decrease vascular smooth muscle reactivity. However, it differs chemically from the thiazides in that it does not possess the thiazide ring system and contains only one sulfonamide group. Indapamide appears to cause vasodilation, probably by inhibiting the passage of calcium and other ions (sodium, potassium) across membranes. This same effect may cause hypokalcemia in susceptible individuals. Indapamide has also been shown to cause uterine myometrial relaxation in experimental animals. Overall, indapamide has an extra-renal antihypertensive action resulting in a decrease in vascular hyperreactivity and a reduction in total peripheral and arteriolar resistance.

Indapamide Absorption

Rapidly absorbed from gastrointestinal tract.

Indapamide side effects and Toxicity

Side effects include electrolyte imbalance (potassium or salt depletion due to too much fluid loss), nausea, stomach disorders, vomiting, weakness

Indapamide Patient Information