Natrilix

Natrilix Brand names, Natrilix Analogs

Natrilix Brand Names Mixture

No information avaliable

Natrilix Chemical_Formula

C₁₆H₁₆ClN₃O₃S

Natrilix RX_link

http://www.rxlist.com/cgi/generic/indap.htm

Natrilix fda sheet

Natrilix FDA

Natrilix msds (material safety sheet)

Natrilix MSDS

Natrilix Synthesis Reference

No information avaliable

Natrilix Molecular Weight

365.835 g/mol

Natrilix Melting Point

161 ^oC

Natrilix H₂O Solubility

75 mg/L

Natrilix State

Solid

Natrilix LogP

2.088

Natrilix Dosage Forms

Tablet

Natrilix Indication

For the treatment of hypertension, alone or in combination with other antihypertensive drugs as well as for the treatment of salt and fluid retention associated with congestive heart failure or edema from pregnancy.

Natrilix Pharmacology

Indapamide is an antihypertensive and a diuretic. It contains both a polar sulfamoyl chlorobenzamide moiety and a lipid- soluble methylindoline moiety. Indapamide bears a structural similarity to the triazide diuretics which are known to decrease vascular smooth muscle reactivity. However, it differs chemically from the thiazides in that it does not possess the thiazide ring system and contains only one sulfonamide group. Indapamide appears to cause vasodilation, probably by inhibiting the passage of calcium and other ions (sodium, potassium) across membranes. This same effect may cause hypokalcemia in susceptible individuals. Indapamide has also been shown to cause uterine myometrial relaxation in experimental animals. Overall, indapamide has an extra-renal antihypertensive action resulting in a decrease in vascular hyperreactivity and a reduction in total peripheral and arteriolar resistance.

Natrilix Absorption

Rapidly absorbed from gastrointestinal tract.

Natrilix side effects and Toxicity

Side effects include electrolyte imbalance (potassium or salt depletion due to too much fluid loss), nausea, stomach disorders, vomiting, weakness

Natrilix Patient Information