Lozide

Lozide Brand names, Lozide Analogs

Lozide Brand Names Mixture

No information avaliable

Lozide Chemical_Formula

C₁₆H₁₆ClN₃O₃S

Lozide RX_link

http://www.rxlist.com/cgi/generic/indap.htm

Lozide fda sheet

Lozide FDA

Lozide msds (material safety sheet)

Lozide MSDS

Lozide Synthesis Reference

No information avaliable

Lozide Molecular Weight

365.835 g/mol

Lozide Melting Point

161 ^oC

Lozide H₂O Solubility

75 mg/L

Lozide State

Solid

Lozide LogP

2.088

Lozide Dosage Forms

Tablet

Lozide Indication

For the treatment of hypertension, alone or in combination with other antihypertensive drugs as well as for the treatment of salt and fluid retention associated with congestive heart failure or edema from pregnancy.

Lozide Pharmacology

Indapamide is an antihypertensive and a diuretic. It contains both a polar sulfamoyl chlorobenzamide moiety and a lipid- soluble methylindoline moiety. Indapamide bears a structural similarity to the triazide diuretics which are known to decrease vascular smooth muscle reactivity. However, it differs chemically from the thiazides in that it does not possess the thiazide ring system and contains only one sulfonamide group. Indapamide appears to cause vasodilation, probably by inhibiting the passage of calcium and other ions (sodium, potassium) across membranes. This same effect may cause hypokalcemia in susceptible individuals. Indapamide has also been shown to cause uterine myometrial relaxation in experimental animals. Overall, indapamide has an extra-renal antihypertensive action resulting in a decrease in vascular hyperreactivity and a reduction in total peripheral and arteriolar resistance.

Lozide Absorption

Rapidly absorbed from gastrointestinal tract.

Lozide side effects and Toxicity

Side effects include electrolyte imbalance (potassium or salt depletion due to too much fluid loss), nausea, stomach disorders, vomiting, weakness

Lozide Patient Information