Indapamida [INN-Spanish]

• Antihypertensive Agents
• Diuretics, Sulfamyl
• ATC:C03BA11

• Apo-Indapamide
• Arifon
• Bajaten
• Cormil
• Damide
• Fludex
• Gen-Indapamide
• Idapamide
• Indaflex
• Indamol
• Indapamida [INN-Spanish]
• Indapamidum
• Indapamidum [INN-Latin]
• Ipamix
• Lozide
• Lozol
• Natrilix
• Natrix
• Noranat
• Novo-Indapamide
• Nu-Indapamide
• Pressurai
• Pressural [as hemihydrate]
• Tandix
• Tertensif
• Veroxil

• No information avaliable

C₁₆H₁₆ClN₃O₃S

http://www.rxlist.com/cgi/generic/indap.htm

Indapamida_[INN-Spanish] FDA

Indapamida_[INN-Spanish] MSDS

No information avaliable

365.835 g/mol

161 ^oC

75 mg/L

Solid

2.088

Tablet

For the treatment of hypertension, alone or in combination with other antihypertensive drugs as well as for the treatment of salt and fluid retention associated with congestive heart failure or edema from pregnancy.

Indapamide is an antihypertensive and a diuretic. It contains both a polar sulfamoyl chlorobenzamide moiety and a lipid- soluble methylindoline moiety. Indapamide bears a structural similarity to the triazide diuretics which are known to decrease vascular smooth muscle reactivity. However, it differs chemically from the thiazides in that it does not possess the thiazide ring system and contains only one sulfonamide group. Indapamide appears to cause vasodilation, probably by inhibiting the passage of calcium and other ions (sodium, potassium) across membranes. This same effect may cause hypokalcemia in susceptible individuals. Indapamide has also been shown to cause uterine myometrial relaxation in experimental animals. Overall, indapamide has an extra-renal antihypertensive action resulting in a decrease in vascular hyperreactivity and a reduction in total peripheral and arteriolar resistance.

Rapidly absorbed from gastrointestinal tract.

Side effects include electrolyte imbalance (potassium or salt depletion due to too much fluid loss), nausea, stomach disorders, vomiting, weakness

No information avaliable

Humans and other mammals