Indapamida [INN-Spanish] en es it fr

Indapamida [INN-Spanish] Brand names, Indapamida [INN-Spanish] Analogs

Indapamida [INN-Spanish] Brand Names Mixture

  • No information avaliable

Indapamida [INN-Spanish] Chemical_Formula


Indapamida [INN-Spanish] RX_link

Indapamida [INN-Spanish] fda sheet

Indapamida_[INN-Spanish] FDA

Indapamida [INN-Spanish] msds (material safety sheet)

Indapamida_[INN-Spanish] MSDS

Indapamida [INN-Spanish] Synthesis Reference

No information avaliable

Indapamida [INN-Spanish] Molecular Weight

365.835 g/mol

Indapamida [INN-Spanish] Melting Point

161 oC

Indapamida [INN-Spanish] H2O Solubility

75 mg/L

Indapamida [INN-Spanish] State


Indapamida [INN-Spanish] LogP


Indapamida [INN-Spanish] Dosage Forms


Indapamida [INN-Spanish] Indication

For the treatment of hypertension, alone or in combination with other antihypertensive drugs as well as for the treatment of salt and fluid retention associated with congestive heart failure or edema from pregnancy.

Indapamida [INN-Spanish] Pharmacology

Indapamide is an antihypertensive and a diuretic. It contains both a polar sulfamoyl chlorobenzamide moiety and a lipid- soluble methylindoline moiety. Indapamide bears a structural similarity to the triazide diuretics which are known to decrease vascular smooth muscle reactivity. However, it differs chemically from the thiazides in that it does not possess the thiazide ring system and contains only one sulfonamide group. Indapamide appears to cause vasodilation, probably by inhibiting the passage of calcium and other ions (sodium, potassium) across membranes. This same effect may cause hypokalcemia in susceptible individuals. Indapamide has also been shown to cause uterine myometrial relaxation in experimental animals. Overall, indapamide has an extra-renal antihypertensive action resulting in a decrease in vascular hyperreactivity and a reduction in total peripheral and arteriolar resistance.

Indapamida [INN-Spanish] Absorption

Rapidly absorbed from gastrointestinal tract.

Indapamida [INN-Spanish] side effects and Toxicity

Side effects include electrolyte imbalance (potassium or salt depletion due to too much fluid loss), nausea, stomach disorders, vomiting, weakness

Indapamida [INN-Spanish] Patient Information

No information avaliable

Indapamida [INN-Spanish] Organisms Affected

Humans and other mammals