Nu-Indapamide
Nu-Indapamide Brand names, Nu-Indapamide Analogs
Nu-Indapamide Brand Names Mixture
- No information avaliable
Nu-Indapamide Chemical_Formula
C16H16ClN3O3S
Nu-Indapamide RX_link
http://www.rxlist.com/cgi/generic/indap.htm
Nu-Indapamide fda sheet
Nu-Indapamide msds (material safety sheet)
Nu-Indapamide Synthesis Reference
No information avaliable
Nu-Indapamide Molecular Weight
365.835 g/mol
Nu-Indapamide Melting Point
161 oC
Nu-Indapamide H2O Solubility
75 mg/L
Nu-Indapamide State
Solid
Nu-Indapamide LogP
2.088
Nu-Indapamide Dosage Forms
Tablet
Nu-Indapamide Indication
For the treatment of hypertension, alone or in combination with other antihypertensive drugs as well as for the treatment of salt and fluid retention associated with congestive heart failure or edema from pregnancy.
Nu-Indapamide Pharmacology
Indapamide is an antihypertensive and a diuretic. It contains both a polar sulfamoyl chlorobenzamide moiety and a lipid- soluble methylindoline moiety. Indapamide bears a structural similarity to the triazide diuretics which are known to decrease vascular smooth muscle reactivity. However, it differs chemically from the thiazides in that it does not possess the thiazide ring system and contains only one sulfonamide group. Indapamide appears to cause vasodilation, probably by inhibiting the passage of calcium and other ions (sodium, potassium) across membranes. This same effect may cause hypokalcemia in susceptible individuals. Indapamide has also been shown to cause uterine myometrial relaxation in experimental animals. Overall, indapamide has an extra-renal antihypertensive action resulting in a decrease in vascular hyperreactivity and a reduction in total peripheral and arteriolar resistance.
Nu-Indapamide Absorption
Rapidly absorbed from gastrointestinal tract.
Nu-Indapamide side effects and Toxicity
Side effects include electrolyte imbalance (potassium or salt depletion due to too much fluid loss), nausea, stomach disorders, vomiting, weakness
Nu-Indapamide Patient Information
No information avaliable
Nu-Indapamide Organisms Affected
Humans and other mammals
