Lozol
Brand names,
Lozol
Analogs
Lozol
Brand Names Mixture
Lozol
Chemical_Formula
C16H16ClN3O3S
Lozol
RX_link
http://www.rxlist.com/cgi/generic/indap.htm
Lozol
fda sheet
Lozol
msds (material safety sheet)
Lozol
Synthesis Reference
No information avaliable
Lozol
Molecular Weight
365.835 g/mol
Lozol
Melting Point
161 oC
Lozol
H2O Solubility
75 mg/L
Lozol
State
Solid
Lozol
LogP
2.088
Lozol
Dosage Forms
Tablet
Lozol
Indication
For the treatment of hypertension, alone or in combination with other antihypertensive drugs as well as for the treatment of salt and fluid retention associated with congestive heart failure or edema from pregnancy.
Lozol
Pharmacology
Indapamide is an antihypertensive and a diuretic. It contains both a polar sulfamoyl chlorobenzamide moiety and a lipid- soluble methylindoline moiety. Indapamide bears a structural similarity to the triazide diuretics which are known to decrease vascular smooth muscle reactivity. However, it differs chemically from the thiazides in that it does not possess the thiazide ring system and contains only one sulfonamide group. Indapamide appears to cause vasodilation, probably by inhibiting the passage of calcium and other ions (sodium, potassium) across membranes. This same effect may cause hypokalcemia in susceptible individuals. Indapamide has also been shown to cause uterine myometrial relaxation in experimental animals. Overall, indapamide has an extra-renal antihypertensive action resulting in a decrease in vascular hyperreactivity and a reduction in total peripheral and arteriolar resistance.
Lozol
Absorption
Rapidly absorbed from gastrointestinal tract.
Lozol
side effects and Toxicity
Side effects include electrolyte imbalance (potassium or salt depletion due to too much fluid loss), nausea, stomach disorders, vomiting, weakness
Lozol
Patient Information
No information avaliable
Lozol
Organisms Affected
Humans and other mammals