Guanfacine
Guanfacine Brand names, Guanfacine Analogs
Guanfacine Brand Names Mixture
- No information avaliable
Guanfacine Chemical_Formula
C9H9Cl2N3O
Guanfacine RX_link
http://www.rxlist.com/cgi/generic3/guanfacine.htm
Guanfacine fda sheet
Guanfacine msds (material safety sheet)
Guanfacine Synthesis Reference
J. B. Bream, C.W. Coward et al.; U.S. Pat. 3,632,645 (1972)
Guanfacine Molecular Weight
246.093 g/mol
Guanfacine Melting Point
225-227 oC
Guanfacine H2O Solubility
1892 mg/L
Guanfacine State
Solid
Guanfacine LogP
2.464
Guanfacine Dosage Forms
Tablet (oral)
Guanfacine Indication
For use in the management of hypertension.
Guanfacine Pharmacology
Similar to clonidine, guanfacine is a centrally-acting, alpha(2)-adrenergic receptor agonist used alone or in combination with other drugs for the treatment of hypertension.
Guanfacine Absorption
Rapid and complete, with an oral bioavailability of approximately 80%.
Guanfacine side effects and Toxicity
Symptoms of overdose include drowsiness, lethargy, bradycardia and hypotension. LD50=165mg/kg (orally in mice)
Guanfacine Patient Information
Patients who receive guanfacine should be advised to exercise caution when operating dangerous machinery or driving motor vehicles until it is determined that they do not become drowsy or dizzy from the medication. Patients should be warned that their tolerance for alcohol and other CNS depressants may be diminished. Patients should be advised not to discontinue therapy abruptly.
Guanfacine Organisms Affected
Humans and other mammals
