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Guanfacine Brand names, Guanfacine Analogs

Guanfacine Brand Names Mixture

  • No information avaliable

Guanfacine Chemical_Formula


Guanfacine RX_link

Guanfacine fda sheet

Guanfacine msds (material safety sheet)

Guanfacine Synthesis Reference

J. B. Bream, C.W. Coward et al.; U.S. Pat. 3,632,645 (1972)

Guanfacine Molecular Weight

246.093 g/mol

Guanfacine Melting Point

225-227 oC

Guanfacine H2O Solubility

1892 mg/L

Guanfacine State


Guanfacine LogP


Guanfacine Dosage Forms

Tablet (oral)

Guanfacine Indication

For use in the management of hypertension.

Guanfacine Pharmacology

Similar to clonidine, guanfacine is a centrally-acting, alpha(2)-adrenergic receptor agonist used alone or in combination with other drugs for the treatment of hypertension.

Guanfacine Absorption

Rapid and complete, with an oral bioavailability of approximately 80%.

Guanfacine side effects and Toxicity

Symptoms of overdose include drowsiness, lethargy, bradycardia and hypotension. LD50=165mg/kg (orally in mice)

Guanfacine Patient Information

Patients who receive guanfacine should be advised to exercise caution when operating dangerous machinery or driving motor vehicles until it is determined that they do not become drowsy or dizzy from the medication. Patients should be warned that their tolerance for alcohol and other CNS depressants may be diminished. Patients should be advised not to discontinue therapy abruptly.

Guanfacine Organisms Affected

Humans and other mammals