Estulic
Estulic Brand names, Estulic Analogs
Estulic Brand Names Mixture
- No information avaliable
Estulic Chemical_Formula
C9H9Cl2N3O
Estulic RX_link
http://www.rxlist.com/cgi/generic3/guanfacine.htm
Estulic fda sheet
Estulic msds (material safety sheet)
Estulic Synthesis Reference
J. B. Bream, C.W. Coward et al.; U.S. Pat. 3,632,645 (1972)
Estulic Molecular Weight
246.093 g/mol
Estulic Melting Point
225-227 oC
Estulic H2O Solubility
1892 mg/L
Estulic State
Solid
Estulic LogP
2.464
Estulic Dosage Forms
Tablet (oral)
Estulic Indication
For use in the management of hypertension.
Estulic Pharmacology
Similar to clonidine, guanfacine is a centrally-acting, alpha(2)-adrenergic receptor agonist used alone or in combination with other drugs for the treatment of hypertension.
Estulic Absorption
Rapid and complete, with an oral bioavailability of approximately 80%.
Estulic side effects and Toxicity
Symptoms of overdose include drowsiness, lethargy, bradycardia and hypotension. LD50=165mg/kg (orally in mice)
Estulic Patient Information
Patients who receive guanfacine should be advised to exercise caution when operating dangerous machinery or driving motor vehicles until it is determined that they do not become drowsy or dizzy from the medication. Patients should be warned that their tolerance for alcohol and other CNS depressants may be diminished. Patients should be advised not to discontinue therapy abruptly.
Estulic Organisms Affected
Humans and other mammals
