Guanfacine HCl
Guanfacine HCl Brand names, Guanfacine HCl Analogs
Guanfacine HCl Brand Names Mixture
- No information avaliable
Guanfacine HCl Chemical_Formula
C9H9Cl2N3O
Guanfacine HCl RX_link
http://www.rxlist.com/cgi/generic3/guanfacine.htm
Guanfacine HCl fda sheet
Guanfacine HCl msds (material safety sheet)
Guanfacine HCl Synthesis Reference
J. B. Bream, C.W. Coward et al.; U.S. Pat. 3,632,645 (1972)
Guanfacine HCl Molecular Weight
246.093 g/mol
Guanfacine HCl Melting Point
225-227 oC
Guanfacine HCl H2O Solubility
1892 mg/L
Guanfacine HCl State
Solid
Guanfacine HCl LogP
2.464
Guanfacine HCl Dosage Forms
Tablet (oral)
Guanfacine HCl Indication
For use in the management of hypertension.
Guanfacine HCl Pharmacology
Similar to clonidine, guanfacine is a centrally-acting, alpha(2)-adrenergic receptor agonist used alone or in combination with other drugs for the treatment of hypertension.
Guanfacine HCl Absorption
Rapid and complete, with an oral bioavailability of approximately 80%.
Guanfacine HCl side effects and Toxicity
Symptoms of overdose include drowsiness, lethargy, bradycardia and hypotension. LD50=165mg/kg (orally in mice)
Guanfacine HCl Patient Information
Patients who receive guanfacine should be advised to exercise caution when operating dangerous machinery or driving motor vehicles until it is determined that they do not become drowsy or dizzy from the medication. Patients should be warned that their tolerance for alcohol and other CNS depressants may be diminished. Patients should be advised not to discontinue therapy abruptly.
Guanfacine HCl Organisms Affected
Humans and other mammals
