Tenex
Tenex Brand names, Tenex Analogs
Tenex Brand Names Mixture
- No information avaliable
Tenex Chemical_Formula
C9H9Cl2N3O
Tenex RX_link
http://www.rxlist.com/cgi/generic3/guanfacine.htm
Tenex fda sheet
Tenex msds (material safety sheet)
Tenex Synthesis Reference
J. B. Bream, C.W. Coward et al.; U.S. Pat. 3,632,645 (1972)
Tenex Molecular Weight
246.093 g/mol
Tenex Melting Point
225-227 oC
Tenex H2O Solubility
1892 mg/L
Tenex State
Solid
Tenex LogP
2.464
Tenex Dosage Forms
Tablet (oral)
Tenex Indication
For use in the management of hypertension.
Tenex Pharmacology
Similar to clonidine, guanfacine is a centrally-acting, alpha(2)-adrenergic receptor agonist used alone or in combination with other drugs for the treatment of hypertension.
Tenex Absorption
Rapid and complete, with an oral bioavailability of approximately 80%.
Tenex side effects and Toxicity
Symptoms of overdose include drowsiness, lethargy, bradycardia and hypotension. LD50=165mg/kg (orally in mice)
Tenex Patient Information
Patients who receive guanfacine should be advised to exercise caution when operating dangerous machinery or driving motor vehicles until it is determined that they do not become drowsy or dizzy from the medication. Patients should be warned that their tolerance for alcohol and other CNS depressants may be diminished. Patients should be advised not to discontinue therapy abruptly.
Tenex Organisms Affected
Humans and other mammals
