Guanfacine Hydrochloride
Guanfacine Hydrochloride Brand names, Guanfacine Hydrochloride Analogs
Guanfacine Hydrochloride Brand Names Mixture
- No information avaliable
Guanfacine Hydrochloride Chemical_Formula
C9H9Cl2N3O
Guanfacine Hydrochloride RX_link
http://www.rxlist.com/cgi/generic3/guanfacine.htm
Guanfacine Hydrochloride fda sheet
Guanfacine Hydrochloride msds (material safety sheet)
Guanfacine Hydrochloride Synthesis Reference
J. B. Bream, C.W. Coward et al.; U.S. Pat. 3,632,645 (1972)
Guanfacine Hydrochloride Molecular Weight
246.093 g/mol
Guanfacine Hydrochloride Melting Point
225-227 oC
Guanfacine Hydrochloride H2O Solubility
1892 mg/L
Guanfacine Hydrochloride State
Solid
Guanfacine Hydrochloride LogP
2.464
Guanfacine Hydrochloride Dosage Forms
Tablet (oral)
Guanfacine Hydrochloride Indication
For use in the management of hypertension.
Guanfacine Hydrochloride Pharmacology
Similar to clonidine, guanfacine is a centrally-acting, alpha(2)-adrenergic receptor agonist used alone or in combination with other drugs for the treatment of hypertension.
Guanfacine Hydrochloride Absorption
Rapid and complete, with an oral bioavailability of approximately 80%.
Guanfacine Hydrochloride side effects and Toxicity
Symptoms of overdose include drowsiness, lethargy, bradycardia and hypotension. LD50=165mg/kg (orally in mice)
Guanfacine Hydrochloride Patient Information
Patients who receive guanfacine should be advised to exercise caution when operating dangerous machinery or driving motor vehicles until it is determined that they do not become drowsy or dizzy from the medication. Patients should be warned that their tolerance for alcohol and other CNS depressants may be diminished. Patients should be advised not to discontinue therapy abruptly.
Guanfacine Hydrochloride Organisms Affected
Humans and other mammals
