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Guanfacine Hydrochloride Brand names, Guanfacine Hydrochloride Analogs

Guanfacine Hydrochloride Brand Names Mixture

  • No information avaliable

Guanfacine Hydrochloride Chemical_Formula

C9H9Cl2N3O

Guanfacine Hydrochloride RX_link

http://www.rxlist.com/cgi/generic3/guanfacine.htm

Guanfacine Hydrochloride fda sheet

Guanfacine Hydrochloride msds (material safety sheet)

Guanfacine Hydrochloride Synthesis Reference

J. B. Bream, C.W. Coward et al.; U.S. Pat. 3,632,645 (1972)

Guanfacine Hydrochloride Molecular Weight

246.093 g/mol

Guanfacine Hydrochloride Melting Point

225-227 oC

Guanfacine Hydrochloride H2O Solubility

1892 mg/L

Guanfacine Hydrochloride State

Solid

Guanfacine Hydrochloride LogP

2.464

Guanfacine Hydrochloride Dosage Forms

Tablet (oral)

Guanfacine Hydrochloride Indication

For use in the management of hypertension.

Guanfacine Hydrochloride Pharmacology

Similar to clonidine, guanfacine is a centrally-acting, alpha(2)-adrenergic receptor agonist used alone or in combination with other drugs for the treatment of hypertension.

Guanfacine Hydrochloride Absorption

Rapid and complete, with an oral bioavailability of approximately 80%.

Guanfacine Hydrochloride side effects and Toxicity

Symptoms of overdose include drowsiness, lethargy, bradycardia and hypotension. LD50=165mg/kg (orally in mice)

Guanfacine Hydrochloride Patient Information

Patients who receive guanfacine should be advised to exercise caution when operating dangerous machinery or driving motor vehicles until it is determined that they do not become drowsy or dizzy from the medication. Patients should be warned that their tolerance for alcohol and other CNS depressants may be diminished. Patients should be advised not to discontinue therapy abruptly.

Guanfacine Hydrochloride Organisms Affected

Humans and other mammals