Galantamine
Galantamine Brand names, Galantamine Analogs
Galantamine Brand Names Mixture
- No information avaliable
Galantamine Chemical_Formula
C17H21NO3
Galantamine RX_link
http://www.rxlist.com/cgi/generic/reminyl.htm
Galantamine fda sheet
Galantamine msds (material safety sheet)
Galantamine Synthesis Reference
Czollner, L. et al. ARKIVOC 191-200 (2001).
Galantamine Molecular Weight
287.354 g/mol
Galantamine Melting Point
269-270 oC (HBr salt)
Galantamine H2O Solubility
10 mg/mL (HBr salt)
Galantamine State
Solid
Galantamine LogP
2.369
Galantamine Dosage Forms
Capsules (extended-release)
Galantamine Indication
For the treatment of mild to moderate dementia of the Alzheimer's type.
Galantamine Pharmacology
Galantamine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. Galantamine is indicated for the treatment of mild to moderate dementia of the Alzheimer's type. Galantamine is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. If this proposed mechanism of action is correct, Galantamine's effect may lessen as the disease process advances and fewer cholinergic neurons remain functionally intact. There is no evidence that Galantamine alters the course of the underlying dementing process.
Galantamine Absorption
No information avaliable
Galantamine side effects and Toxicity
LD50=75 mg/kg (rat)
Galantamine Patient Information
Galantamine is used to treat the symptoms of Alzheimer's disease (AD; a brain disease that slowly destroys the memory and the ability to think, learn, communicate and handle daily activities). Galantamine is in a class of medications called acetylcholinesterase inhibitors. It works by increasing the amount of a certain natural substance in the brain that is needed for memory and thought. Galantamine may improve the ability to think and remember or slow the loss of these abilities in people who have AD. However, galantamine will not cure AD or prevent the loss of mental abilities at some time in the future.
Galantamine Organisms Affected
Humans and other mammals
