Galantamin
Galantamin Brand names, Galantamin Analogs
Galantamin Brand Names Mixture
- No information avaliable
Galantamin Chemical_Formula
C17H21NO3
Galantamin RX_link
http://www.rxlist.com/cgi/generic/reminyl.htm
Galantamin fda sheet
Galantamin msds (material safety sheet)
Galantamin Synthesis Reference
Czollner, L. et al. ARKIVOC 191-200 (2001).
Galantamin Molecular Weight
287.354 g/mol
Galantamin Melting Point
269-270 oC (HBr salt)
Galantamin H2O Solubility
10 mg/mL (HBr salt)
Galantamin State
Solid
Galantamin LogP
2.369
Galantamin Dosage Forms
Capsules (extended-release)
Galantamin Indication
For the treatment of mild to moderate dementia of the Alzheimer's type.
Galantamin Pharmacology
Galantamine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. Galantamine is indicated for the treatment of mild to moderate dementia of the Alzheimer's type. Galantamine is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. If this proposed mechanism of action is correct, Galantamine's effect may lessen as the disease process advances and fewer cholinergic neurons remain functionally intact. There is no evidence that Galantamine alters the course of the underlying dementing process.
Galantamin Absorption
No information avaliable
Galantamin side effects and Toxicity
LD50=75 mg/kg (rat)
Galantamin Patient Information
Galantamine is used to treat the symptoms of Alzheimer's disease (AD; a brain disease that slowly destroys the memory and the ability to think, learn, communicate and handle daily activities). Galantamine is in a class of medications called acetylcholinesterase inhibitors. It works by increasing the amount of a certain natural substance in the brain that is needed for memory and thought. Galantamine may improve the ability to think and remember or slow the loss of these abilities in people who have AD. However, galantamine will not cure AD or prevent the loss of mental abilities at some time in the future.
Galantamin Organisms Affected
Humans and other mammals
