Galanthamine base
Galanthamine base Brand names, Galanthamine base Analogs
Galanthamine base Brand Names Mixture
- No information avaliable
Galanthamine base Chemical_Formula
C17H21NO3
Galanthamine base RX_link
http://www.rxlist.com/cgi/generic/reminyl.htm
Galanthamine base fda sheet
Galanthamine base msds (material safety sheet)
Galanthamine base Synthesis Reference
Czollner, L. et al. ARKIVOC 191-200 (2001).
Galanthamine base Molecular Weight
287.354 g/mol
Galanthamine base Melting Point
269-270 oC (HBr salt)
Galanthamine base H2O Solubility
10 mg/mL (HBr salt)
Galanthamine base State
Solid
Galanthamine base LogP
2.369
Galanthamine base Dosage Forms
Capsules (extended-release)
Galanthamine base Indication
For the treatment of mild to moderate dementia of the Alzheimer's type.
Galanthamine base Pharmacology
Galantamine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. Galantamine is indicated for the treatment of mild to moderate dementia of the Alzheimer's type. Galantamine is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. If this proposed mechanism of action is correct, Galantamine's effect may lessen as the disease process advances and fewer cholinergic neurons remain functionally intact. There is no evidence that Galantamine alters the course of the underlying dementing process.
Galanthamine base Absorption
No information avaliable
Galanthamine base side effects and Toxicity
LD50=75 mg/kg (rat)
Galanthamine base Patient Information
Galantamine is used to treat the symptoms of Alzheimer's disease (AD; a brain disease that slowly destroys the memory and the ability to think, learn, communicate and handle daily activities). Galantamine is in a class of medications called acetylcholinesterase inhibitors. It works by increasing the amount of a certain natural substance in the brain that is needed for memory and thought. Galantamine may improve the ability to think and remember or slow the loss of these abilities in people who have AD. However, galantamine will not cure AD or prevent the loss of mental abilities at some time in the future.
Galanthamine base Organisms Affected
Humans and other mammals
