Formoterol
Formoterol Brand names, Formoterol Analogs
Formoterol Brand Names Mixture
- No information avaliable
Formoterol Chemical_Formula
C19H24N2O4
Formoterol RX_link
http://www.rxlist.com/cgi/generic/foradil.htm
Formoterol fda sheet
Formoterol msds (material safety sheet)
Formoterol Synthesis Reference
No information avaliable
Formoterol Molecular Weight
344.405 g/mol
Formoterol Melting Point
No information avaliable
Formoterol H2O Solubility
Slightly (as fumarate salt)
Formoterol State
Solid
Formoterol LogP
2.083
Formoterol Dosage Forms
Metered-dose (aerosol); Powder
Formoterol Indication
For use as long-term maintenance treatment of asthma in patients 6 years of age and older with reversible obstructive airways disease, including patients with symptoms of nocturnal asthma, who are using optimal corticosteroid treatment and experiencing regular or frequent breakthrough symptoms requiring use of a short-acting bronchodilator.
Formoterol Pharmacology
Formoterol is a long-acting selective beta2-adrenergic receptor agonist (beta2-agonist). Inhaled formoterol fumarate acts locally in the lung as a bronchodilator. In vitro studies have shown that formoterol has more than 200-fold greater agonist activity at beta2-receptors than at beta1- receptors. Although beta2-receptors are the predominant adrenergic receptors in bronchial smooth muscle and beta1-receptors are the predominant receptors in the heart, there are also beta2-receptors in the human heart comprising 10%-50% of the total beta-adrenergic receptors. The precise function of these receptors has not been established, but they raise the possibility that even highly selective beta2- agonists may have cardiac effects.
Formoterol Absorption
Rapidly absorbed into plasma following administration by oral inhalation. It is likely that the majority of the inhaled formoterol delivered is swallowed and then absorbed from the gastrointestinal tract.
Formoterol side effects and Toxicity
An overdosage is likely to lead to effects that are typical of ß2-adrenergic stimulants: nausea, vomiting, headache, tremor, somnolence, palpitations, tachycardia, ventricular arrhythmias, metabolic acidosis, hypokalemia, hyperglycemia.
Formoterol Patient Information
Formoterol Organisms Affected
Humans and other mammals
