Formoterolum [Inn-Latin]
Brand names,
Formoterolum [Inn-Latin]
Analogs
Formoterolum [Inn-Latin]
Brand Names Mixture
Formoterolum [Inn-Latin]
Chemical_Formula
C19H24N2O4
Formoterolum [Inn-Latin]
RX_link
http://www.rxlist.com/cgi/generic/foradil.htm
Formoterolum [Inn-Latin]
fda sheet
Formoterolum [Inn-Latin]
msds (material safety sheet)
Formoterolum [Inn-Latin]
Synthesis Reference
No information avaliable
Formoterolum [Inn-Latin]
Molecular Weight
344.405 g/mol
Formoterolum [Inn-Latin]
Melting Point
No information avaliable
Formoterolum [Inn-Latin]
H2O Solubility
Slightly (as fumarate salt)
Formoterolum [Inn-Latin]
State
Solid
Formoterolum [Inn-Latin]
LogP
2.083
Formoterolum [Inn-Latin]
Dosage Forms
Metered-dose (aerosol); Powder
Formoterolum [Inn-Latin]
Indication
For use as long-term maintenance treatment of asthma in patients 6 years of age and older with reversible obstructive airways disease, including patients with symptoms of nocturnal asthma, who are using optimal corticosteroid treatment and experiencing regular or frequent breakthrough symptoms requiring use of a short-acting bronchodilator.
Formoterolum [Inn-Latin]
Pharmacology
Formoterol is a long-acting selective beta2-adrenergic receptor agonist (beta2-agonist). Inhaled formoterol fumarate acts locally in the lung as a bronchodilator. In vitro studies have shown that formoterol has more than 200-fold greater agonist activity at beta2-receptors than at beta1- receptors. Although beta2-receptors are the predominant adrenergic receptors in bronchial smooth muscle and beta1-receptors are the predominant receptors in the heart, there are also beta2-receptors in the human heart comprising 10%-50% of the total beta-adrenergic receptors. The precise function of these receptors has not been established, but they raise the possibility that even highly selective beta2- agonists may have cardiac effects.
Formoterolum [Inn-Latin]
Absorption
Rapidly absorbed into plasma following administration by oral inhalation. It is likely that the majority of the inhaled formoterol delivered is swallowed and then absorbed from the gastrointestinal tract.
Formoterolum [Inn-Latin]
side effects and Toxicity
An overdosage is likely to lead to effects that are typical of ß2-adrenergic stimulants: nausea, vomiting, headache, tremor, somnolence, palpitations, tachycardia, ventricular arrhythmias, metabolic acidosis, hypokalemia, hyperglycemia.
Formoterolum [Inn-Latin]
Patient Information
Formoterolum [Inn-Latin]
Organisms Affected
Humans and other mammals