Formoterol fumarate
Formoterol fumarate Brand names, Formoterol fumarate Analogs
Formoterol fumarate Brand Names Mixture
- No information avaliable
Formoterol fumarate Chemical_Formula
C19H24N2O4
Formoterol fumarate RX_link
http://www.rxlist.com/cgi/generic/foradil.htm
Formoterol fumarate fda sheet
Formoterol fumarate msds (material safety sheet)
Formoterol fumarate Synthesis Reference
No information avaliable
Formoterol fumarate Molecular Weight
344.405 g/mol
Formoterol fumarate Melting Point
No information avaliable
Formoterol fumarate H2O Solubility
Slightly (as fumarate salt)
Formoterol fumarate State
Solid
Formoterol fumarate LogP
2.083
Formoterol fumarate Dosage Forms
Metered-dose (aerosol); Powder
Formoterol fumarate Indication
For use as long-term maintenance treatment of asthma in patients 6 years of age and older with reversible obstructive airways disease, including patients with symptoms of nocturnal asthma, who are using optimal corticosteroid treatment and experiencing regular or frequent breakthrough symptoms requiring use of a short-acting bronchodilator.
Formoterol fumarate Pharmacology
Formoterol is a long-acting selective beta2-adrenergic receptor agonist (beta2-agonist). Inhaled formoterol fumarate acts locally in the lung as a bronchodilator. In vitro studies have shown that formoterol has more than 200-fold greater agonist activity at beta2-receptors than at beta1- receptors. Although beta2-receptors are the predominant adrenergic receptors in bronchial smooth muscle and beta1-receptors are the predominant receptors in the heart, there are also beta2-receptors in the human heart comprising 10%-50% of the total beta-adrenergic receptors. The precise function of these receptors has not been established, but they raise the possibility that even highly selective beta2- agonists may have cardiac effects.
Formoterol fumarate Absorption
Rapidly absorbed into plasma following administration by oral inhalation. It is likely that the majority of the inhaled formoterol delivered is swallowed and then absorbed from the gastrointestinal tract.
Formoterol fumarate side effects and Toxicity
An overdosage is likely to lead to effects that are typical of ß2-adrenergic stimulants: nausea, vomiting, headache, tremor, somnolence, palpitations, tachycardia, ventricular arrhythmias, metabolic acidosis, hypokalemia, hyperglycemia.
Formoterol fumarate Patient Information
Formoterol fumarate Organisms Affected
Humans and other mammals
