Diazon
Brand names,
Diazon
Analogs
Diazon
Brand Names Mixture
Diazon
Chemical_Formula
C14H16N2O6S3
Diazon
RX_link
No information avaliable
Diazon
fda sheet
Diazon
msds (material safety sheet)
Diazon
Synthesis Reference
No information avaliable
Diazon
Molecular Weight
404.485 g/mol
Diazon
Melting Point
No information avaliable
Diazon
H2O Solubility
No information avaliable
Diazon
State
Solid
Diazon
LogP
-1.064
Diazon
Dosage Forms
Tablet
Diazon
Indication
For the treatment of leprosy and dermatitis herpetiformis
Diazon
Pharmacology
Sulfoxone is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Diazon
Absorption
Rapidly absorbed.
Diazon
side effects and Toxicity
Oral, rat LD50: 7000 mg/kg
Diazon
Patient Information
Diazon
Organisms Affected
Enteric bacteria and other eubacteria