Aldapsone
Aldapsone Brand names, Aldapsone Analogs
Aldapsone Brand Names Mixture
- No information avaliable
Aldapsone Chemical_Formula
C14H16N2O6S3
Aldapsone RX_link
No information avaliable
Aldapsone fda sheet
Aldapsone msds (material safety sheet)
Aldapsone Synthesis Reference
No information avaliable
Aldapsone Molecular Weight
404.485 g/mol
Aldapsone Melting Point
No information avaliable
Aldapsone H2O Solubility
No information avaliable
Aldapsone State
Solid
Aldapsone LogP
-1.064
Aldapsone Dosage Forms
Tablet
Aldapsone Indication
For the treatment of leprosy and dermatitis herpetiformis
Aldapsone Pharmacology
Sulfoxone is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Aldapsone Absorption
Rapidly absorbed.
Aldapsone side effects and Toxicity
Oral, rat LD50: 7000 mg/kg
Aldapsone Patient Information
Aldapsone Organisms Affected
Enteric bacteria and other eubacteria
