Bitrop
Brand names,
Bitrop
Analogs
Bitrop
Brand Names Mixture
- Combivent Inhalation Aerosol (Ipratropium Bromide + Salbutamol Sulfate)
- Combivent Inhalation Solution (Ipratropium Bromide + Salbutamol Sulfate)
- Duovent Udv (Fenoterol Hydrobromide + Ipratropium Bromide)
- Ratio-Ipra Sal Udv (Ipratropium Bromide + Salbutamol Sulfate)
Bitrop
Chemical_Formula
C20H30NO3
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RX_link
http://www.rxlist.com/cgi/generic/ipratrop.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
K. Zeile et al.,U.S. Pat. 3,505,337 (1970)
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Molecular Weight
332.457 g/mol
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Melting Point
230-232oC
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H2O Solubility
Freely soluble
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State
Solid
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LogP
No information avaliable
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Dosage Forms
Aerosol (with propellants); Liquid; Metered-dose (aerosol); Metered-dose (pump); Solution
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Indication
For maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease, including chronic bronchitis and emphysema.
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Pharmacology
Ipratropium bromide, a synthetic ammonium compound structurally similar to atropine, is used as a bronchodilator in the management of cholinergic-mediated bronchospasm associated with chronic obstructive pulmonary disease and in the treatment of rhinorrhea associated with the common cold or with allergic or nonallergic seasonal rhinitis.
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Absorption
Inhalation (local)-minimal; Nasal-rapid and minimal
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side effects and Toxicity
LD50=1001mg/kg (orally in mice)
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Patient Information
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Organisms Affected
Humans and other mammals