Bexarotene
Bexarotene Brand names, Bexarotene Analogs
Bexarotene Brand Names Mixture
- No information avaliable
Bexarotene Chemical_Formula
C24H28O2
Bexarotene RX_link
http://www.rxlist.com/cgi/generic3/bexarotene.htm
Bexarotene fda sheet
Bexarotene msds (material safety sheet)
Bexarotene Synthesis Reference
No information avaliable
Bexarotene Molecular Weight
348.478 g/mol
Bexarotene Melting Point
No information avaliable
Bexarotene H2O Solubility
No information avaliable
Bexarotene State
Solid
Bexarotene LogP
8.096
Bexarotene Dosage Forms
No information avaliable
Bexarotene Indication
For the treatment of cutaneous manifestations of cutaneous T-cell lymphoma in patients who are refractory to at least one prior systemic therapy
Bexarotene Pharmacology
Bexarotene is a member of a subclass of retinoids that selectively activate retinoid X receptors (RXRs). These retinoid receptors have biologic activity distinct from that of retinoic acid receptors (RARs). Bexarotene is indicated for the treatment of cutaneous manifestations of cutaneous T-cell lymphoma in patients who are refractory to at least one prior systemic therapy. Bexarotene selectively binds and activates retinoid X receptor subtypes (RXRa, RXRb, RXRg). RXRs can form heterodimers with various receptor partners such as retinoic acid receptors (RARs), vitamin Dy receptor, thyroid receptor, and peroxisome proliferator activator receptors (PPARs). Once activated, these receptors function as transcription factors that regulate the expression of genes that control cellular differentiation and proliferation. Bexarotene inhibits the growth in vitro of some tumor cell lines of hematopoietic and squamous cell origin. It also induces tumor regression in vivo in some animal models.
Bexarotene Absorption
No information avaliable
Bexarotene side effects and Toxicity
No information avaliable
Bexarotene Patient Information
No information avaliable
Bexarotene Organisms Affected
Humans and other mammals
