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Brand names,
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Analogs
Acular Preservative Free
Brand Names Mixture
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Chemical_Formula
C17H11N5
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RX_link
http://www.rxlist.com/cgi/generic2/letroz.htm
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fda sheet
Acular Preservative Free
msds (material safety sheet)
Acular Preservative Free
Synthesis Reference
No information avaliable
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Molecular Weight
285.303 g/mol
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Melting Point
184-185 oC
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H2O Solubility
No information avaliable
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State
Solid
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LogP
3.385
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Dosage Forms
Tablet
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Indication
For the extended adjuvant treatment of early breast cancer in postmenopausal women who have received 5 years of adjuvant tamoxifen therapy. Also for first-line treatment of postmenopausal women with hormone receptor positive or hormone receptor unknown locally advanced or metastatic breast cancer. Also indicated for the treatment of advanced breast cancer in postmenopausal women with disease progression following antiestrogen therapy.
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Pharmacology
Letrozole is an aromatase inhibitor used in the treatment of breast cancer. Aromatase inhibitors work by inhibiting the action of the enzyme aromatase, which converts androgens into estrogens by a process called aromatization. As breast tissue is stimulated by estrogens, decreasing their production is a way of suppressing recurrence of the breast tumor tissue.
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Absorption
Rapidly and completely absorbed. Absorption is not affected by food.
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side effects and Toxicity
No information avaliable
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Patient Information
No information avaliable
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Organisms Affected
Humans and other mammals