AZT
Brand names,
AZT
Analogs
AZT
Brand Names Mixture
AZT
Chemical_Formula
C38H72N2O12
AZT
RX_link
http://www.rxlist.com/cgi/generic/azith.htm
AZT
fda sheet
AZT
msds (material safety sheet)
AZT
Synthesis Reference
G.Kobrehel, S.Djokic, U.S. pat. 4,517,359 (1982, 1985 to Sour Pliva)
AZT
Molecular Weight
748.985 g/mol
AZT
Melting Point
113-115 oC
AZT
H2O Solubility
slight
AZT
State
Solid
AZT
LogP
2.461
AZT
Dosage Forms
Oral suspension; Capsule; Tablet; Powder for solution
AZT
Indication
For the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms in the specific conditions: H. influenzae, M. catarrhalis, S. pneumoniae, C. pneumoniae, M. pneumoniae, S. pyogenes, S. aureus, S. agal
AZT
Pharmacology
Azithromycin, a semisynthetic antibiotic belonging to the macrolide subgroup of azalides, is used to treat STDs due to chlamydia and gonorrhea, community-acquired pneumonia, pelvic inflammatory disease, pediatric otitis media and pharyngitis, and Mycobacterium avium complex (MAC) in patients with advanced HIV disease. Similar in structure to erythromycin. azithromycin reaches higher intracellular concentrations than erythromycin, increasing its efficacy and duration of action.
AZT
Absorption
37% (oral administration)
AZT
side effects and Toxicity
Potentially serious side effects of angioedema and cholestatic jaundice were reported
AZT
Patient Information
Patients should be instructed to take Zmax on an empty stomach (at least 1 hour before or 2 hours following a
meal).
Patients should be instructed to immediately contact a physician if any signs of an allergic reaction occur.
Patients who vomit within the first hour should contact their health care provider about further treatment.
Keep bottle tightly closed. Store at room temperature. Use within 12 hours of constitution. Shake bottle well
before use. The entire contents of the bottle should be consumed.
Patients should be advised that Zmax may be taken without regard to antacids containing magnesium hydroxide and/or
aluminum hydroxide.
Patients should be counseled that antibacterial drugs including Zmax should only be used to treat bacterial
infections. They do not treat viral infections (e.g., the common cold). Not taking the complete prescribed dose may
(1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop
resistance and will not be treatable by Zmax or other antibacterial drugs in the future.
AZT
Organisms Affected
Enteric bacteria and other eubacteria