Azitromax
Brand names,
Azitromax
Analogs
Azitromax
Brand Names Mixture
Azitromax
Chemical_Formula
C38H72N2O12
Azitromax
RX_link
http://www.rxlist.com/cgi/generic/azith.htm
Azitromax
fda sheet
Azitromax
msds (material safety sheet)
Azitromax
Synthesis Reference
G.Kobrehel, S.Djokic, U.S. pat. 4,517,359 (1982, 1985 to Sour Pliva)
Azitromax
Molecular Weight
748.985 g/mol
Azitromax
Melting Point
113-115 oC
Azitromax
H2O Solubility
slight
Azitromax
State
Solid
Azitromax
LogP
2.461
Azitromax
Dosage Forms
Oral suspension; Capsule; Tablet; Powder for solution
Azitromax
Indication
For the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms in the specific conditions: H. influenzae, M. catarrhalis, S. pneumoniae, C. pneumoniae, M. pneumoniae, S. pyogenes, S. aureus, S. agal
Azitromax
Pharmacology
Azithromycin, a semisynthetic antibiotic belonging to the macrolide subgroup of azalides, is used to treat STDs due to chlamydia and gonorrhea, community-acquired pneumonia, pelvic inflammatory disease, pediatric otitis media and pharyngitis, and Mycobacterium avium complex (MAC) in patients with advanced HIV disease. Similar in structure to erythromycin. azithromycin reaches higher intracellular concentrations than erythromycin, increasing its efficacy and duration of action.
Azitromax
Absorption
37% (oral administration)
Azitromax
side effects and Toxicity
Potentially serious side effects of angioedema and cholestatic jaundice were reported
Azitromax
Patient Information
Patients should be instructed to take Zmax on an empty stomach (at least 1 hour before or 2 hours following a
meal).
Patients should be instructed to immediately contact a physician if any signs of an allergic reaction occur.
Patients who vomit within the first hour should contact their health care provider about further treatment.
Keep bottle tightly closed. Store at room temperature. Use within 12 hours of constitution. Shake bottle well
before use. The entire contents of the bottle should be consumed.
Patients should be advised that Zmax may be taken without regard to antacids containing magnesium hydroxide and/or
aluminum hydroxide.
Patients should be counseled that antibacterial drugs including Zmax should only be used to treat bacterial
infections. They do not treat viral infections (e.g., the common cold). Not taking the complete prescribed dose may
(1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop
resistance and will not be treatable by Zmax or other antibacterial drugs in the future.
Azitromax
Organisms Affected
Enteric bacteria and other eubacteria