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2-Amino 6MP Brand names, 2-Amino 6MP Analogs

2-Amino 6MP Brand Names Mixture

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2-Amino 6MP Chemical_Formula


2-Amino 6MP RX_link


2-Amino 6MP fda sheet

2-Amino_6MP FDA

2-Amino 6MP msds (material safety sheet)

2-Amino_6MP MSDS

2-Amino 6MP Synthesis Reference

Elion et al.; J.Amer.Chem.Soc.; 81;1898,1901 (1959)

2-Amino 6MP Molecular Weight

167.193 g/mol

2-Amino 6MP Melting Point

>360 oC

2-Amino 6MP H2O Solubility

36.3 mg/mL

2-Amino 6MP State


2-Amino 6MP LogP


2-Amino 6MP Dosage Forms

Oral tablets

2-Amino 6MP Indication

For remission induction and remission consolidation treatment of acute nonlymphocytic leukemias.

2-Amino 6MP Pharmacology

Thioguanine is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute nonlymphocytic leukemia. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Thioguanine was first synthesized and entered into clinical trial more than 30 years ago. It is a 6-thiopurine analogue of the naturally occurring purine bases hypoxanthine and guanine. Intracellular activation results in incorporation into DNA as a false purine base. An additional cytotoxic effect is related to its incorporation into RNA. Thioguanine is cross-resistant with mercaptopurine. Cytotoxicity is cell cycle phase-specific (S-phase).

2-Amino 6MP Absorption

Absorption of an oral dose is incomplete and variable, averaging approximately 30% of the administered dose (range: 14% to 46%)

2-Amino 6MP side effects and Toxicity

Oral, mouse: LD50 = 160 mg/kg. Symptoms of overdose include nausea, vomiting, malaise, hypotension, and diaphoresis.

2-Amino 6MP Patient Information


Patients should be informed that the major toxicities of thioguanine are related to
myelosuppression, hepatotoxicity, and gastrointestinal toxicity. Patients should never
be allowed to take the drug without medical supervision and should be advised to consult
their physician if they experience fever, sore throat, jaundice, nausea, vomiting, signs
of local infection, bleeding from any site, or symptoms suggestive of anemia. Women of
childbearing potential should be advised to avoid becoming pregnant.

2-Amino 6MP Organisms Affected

Humans and other mammals