2-Amino-6-purinethiol en es it fr

2-Amino-6-purinethiol Brand names, 2-Amino-6-purinethiol Analogs

2-Amino-6-purinethiol Brand Names Mixture

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2-Amino-6-purinethiol Chemical_Formula


2-Amino-6-purinethiol RX_link


2-Amino-6-purinethiol fda sheet

2-Amino-6-purinethiol FDA

2-Amino-6-purinethiol msds (material safety sheet)

2-Amino-6-purinethiol MSDS

2-Amino-6-purinethiol Synthesis Reference

Elion et al.; J.Amer.Chem.Soc.; 81;1898,1901 (1959)

2-Amino-6-purinethiol Molecular Weight

167.193 g/mol

2-Amino-6-purinethiol Melting Point

>360 oC

2-Amino-6-purinethiol H2O Solubility

36.3 mg/mL

2-Amino-6-purinethiol State


2-Amino-6-purinethiol LogP


2-Amino-6-purinethiol Dosage Forms

Oral tablets

2-Amino-6-purinethiol Indication

For remission induction and remission consolidation treatment of acute nonlymphocytic leukemias.

2-Amino-6-purinethiol Pharmacology

Thioguanine is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute nonlymphocytic leukemia. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Thioguanine was first synthesized and entered into clinical trial more than 30 years ago. It is a 6-thiopurine analogue of the naturally occurring purine bases hypoxanthine and guanine. Intracellular activation results in incorporation into DNA as a false purine base. An additional cytotoxic effect is related to its incorporation into RNA. Thioguanine is cross-resistant with mercaptopurine. Cytotoxicity is cell cycle phase-specific (S-phase).

2-Amino-6-purinethiol Absorption

Absorption of an oral dose is incomplete and variable, averaging approximately 30% of the administered dose (range: 14% to 46%)

2-Amino-6-purinethiol side effects and Toxicity

Oral, mouse: LD50 = 160 mg/kg. Symptoms of overdose include nausea, vomiting, malaise, hypotension, and diaphoresis.

2-Amino-6-purinethiol Patient Information


Patients should be informed that the major toxicities of thioguanine are related to
myelosuppression, hepatotoxicity, and gastrointestinal toxicity. Patients should never
be allowed to take the drug without medical supervision and should be advised to consult
their physician if they experience fever, sore throat, jaundice, nausea, vomiting, signs
of local infection, bleeding from any site, or symptoms suggestive of anemia. Women of
childbearing potential should be advised to avoid becoming pregnant.

2-Amino-6-purinethiol Organisms Affected

Humans and other mammals